Fluvoxamine increases the clozapine serum levels significantly

被引：52

作者：

Koponen, HJ

Leinonen, E

Lepola, U

机构：

[1] UNIV OULU,DEPT PSYCHIAT,OULU,FINLAND

[2] PSYCHIAT RES CTR KUOPIO,KUOPIO,FINLAND

来源：

EUROPEAN NEUROPSYCHOPHARMACOLOGY | 1996年 / 6卷 / 01期

关键词：

clozapine; fluvoxamine; serum drug concentration;

D O I：

10.1016/0924-977X(95)00069-2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In this case report we describe an interaction between clozapine and fluvoxamine in two physically healthy patients meeting the DSM-IIIR criteria for paranoid schizophrenia. The substantial rise of clozapine serum levels suggest that caution should be exercised when combining fluvoxamine with clozapine as the clozapine concentration may increase by a factor of 5-10.

引用

页码：69 / 71

页数：3

共 12 条

[1]

[Anonymous], 1987, DIAGNOSTIC STAT MANU, V4th

[2] CLOZAPINE DISPOSITION COVARIES WITH CYP1A2 ACTIVITY DETERMINED BY A CAFFEINE TEST [J].