The role of GLP-1 in the life and death of pancreatic beta cells

被引：63

作者：

Perfetti, R ^{[1
]}

Hui, H ^{[1
]}

机构：

[1] Cedars Sinai Med Ctr, Div Endocrinol Diabet & Metab, Los Angeles, CA 90048 USA

来源：

HORMONE AND METABOLIC RESEARCH | 2004年 / 36卷 / 11-12期

关键词：

beta-cells; insulin; differentiation; regeneration and apoptosis; diabetes;

D O I：

10.1055/s-2004-826167

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Glucagon-like peptide-1 (GLP-1), a peptide hormone produce by intestinal cells, has recently been shown to be capable of modulating islet cell mass. Administration of GLP-1 to rodent models of type 2 diabetes ameliorates insulin secretion, induces the replication of islet cells, and promotes islet-cell neogenesis from pancreatic ductal cells susceptible to transdifferentiate in insulin-producing cells. In addition, an anti-apoptotic effect of GLP-1 has been described in hyperglycemic animal models, using freshly isolated human islets or cultured beta cell lines exposed to various pro-apoptotic stimuli. The aim of this article is to review those reports that have emphasized the role of GLP-1 as a regulator of islet cell mass.

引用

页码：804 / 810

页数：7

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