Antiphospholipid antibodies or not?: The role of β2 glycoprotein 1 in autoantibody-mediated pregnancy loss

被引:20
作者
Chamley, LW [1 ]
机构
[1] Univ Auckland, Natl Womens Hosp, Dept Obstet & Gynaecol, Auckland 1, New Zealand
关键词
antiphospholipid antibody; lupus anticoagulant; anticardiolipin antibody; beta(2); glycoprotein; 1; miscarriage; still birth; pregnancy;
D O I
10.1016/S0165-0378(97)00063-6
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Antiphospholipid antibodies are a family of autoantibodies including lupus anticoagulant and anticardiolipin antibodies that appear to react with negatively charged phospholipids. These antibodies induce trhombosis and pregnancy complications including recurrent stillbirth, recurrent miscarriage, pre-eclampsia and intra-uterine growth retardation. Recent evidence indicates that antiphospholipid antibodies do not bind directly to phospholipid but rather to phospholipid-binding proteins or to a combination of phospholipid and phospholipid-binding proteins. This opens the possibility that antiphospholipid antibodies may be pathogenic by disrupting the function of phospholipid-binding proteins rather than membrane phospholipid. The antigenic role of one phospholipid-binding protein, beta(2) glycoprotein, has been studied in the greatest detail and is reviewed. Despite being highly conserved and expressed at high levels, the physiological function of beta(2) glycoprotein 1 remains unknown. However, a number of putative roles have been proposed which allow speculation as to the mechanism by which antiphospholipid antibodies may disrupt haemostasis and pregnancy. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码:123 / 142
页数:20
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