Circadian rhythms in plasma cortisone and cortisol and the cortisone/cortisol ratio

被引：44

作者：

Nomura, S ^{[1
]}

Fujitaka, M ^{[1
]}

Sakura, N ^{[1
]}

Ueda, K ^{[1
]}

机构：

[1] Hiroshima Univ, Sch Med, Dept Pediat, Hiroshima, Japan

来源：

CLINICA CHIMICA ACTA | 1997年 / 266卷 / 02期

关键词：

cortisone; cortisol; cortisone/cortisol ratio; circadian rhythm;

D O I：

10.1016/S0009-8981(97)00142-3

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

We evaluated the circadian rhythms in the plasma concentrations of cortisol, cortisone and their free forms, and in the cortisone/cortisol ratios by means of reversed-phase high performance liquid chromatography in normal adult subjects. Plasma concentrations of cortisone, as well as cortisol, exhibited a circadian rhythm. The ratios of cortisone/cortisol remained almost constant during the waking hours of normal subjects. Changes in the cortisone/cortisol ratios previously reported in patients with various diseases exceeded the diurnal changes detected in the present study. Thus, the determination of the cortisone/cortisol ratio provides information that is useful in assessing the adrenal function of patients with various diseases. (C) 1997 Elsevier Science B.V.

引用

页码：83 / 91

页数：9

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