Risk assessment in haematopoietic stem cell transplantation: Pre-transplant patient and donor factors: non-HLA genetics

被引：19

作者：

Dickinson, Anne M. ^{[1
]}

机构：

[1] Univ Newcastle Upon Tyne, Sch Med, Sch Clin & Lab Sci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 2007年 / 20卷 / 02期

关键词：

non-HLA genetics; single-nucleoticle polymorphisms; haematopoietic stem-cell transplantation; graft-versus-host disease;

D O I：

10.1016/j.beha.2006.10.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Non-HLA genetics involving the study of single-nucleotide polymorphisms (SNPs) and micro-satellites of cytokine and cytokine receptor genes, and as well as genes associated with response to infection and therapeutic drugs, are currently being studied for associations with diseases, including autoimmune disease, cancer and solid-organ transplant rejection. This chapter will summarize the potential role of non-HLA genetics in predicting outcome of haematopoietic stem-cell transplantation (HSCT) and how genotyping for non-HLA genes may give insight into the immunobiology of HSCT complications, including GvHD and infectious episodes. Future directions - including the role of pharmacogenomics, use of the research results for individualized medicine, and interpretation of data - will also be discussed.

引用

页码：189 / 207

页数：19

共 94 条

[1]

ABRAHAM LJ, 1993, CLIN EXP IMMUNOL, V92, P14

[2] TGF-β in allogeneic stem cell transplantation:: friend or foe? [J].