Next-generation biomarkers for detecting kidney toxicity

被引：408

作者：

Bonventre, Joseph V. ^{[1
]}

Vaidya, Vishal S. ^{[1
]}

Schmouder, Robert ^{[2
]}

Feig, Peter ^{[3
]}

Dieterle, Frank ^{[4
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Renal,Dept Med, Boston, MA 02115 USA

[2] Novartis Inst BioMed Res, E Hanover, NJ USA

[3] Merck Res Labs, Rahway, NJ USA

[4] Novartis Inst BioMed Res, Basel, Switzerland

来源：

NATURE BIOTECHNOLOGY | 2010年 / 28卷 / 05期

关键词：

INJURY; QUALIFICATION;

D O I：

10.1038/nbt0510-436

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

There is a paucity of biomarkers that reliably detect nephrotoxicity. The Predictive Safety Testing Consortium (PSTC) faced several challenges in identifying novel safety biomarkers in the renal setting.

引用

页码：436 / 440

页数：5

共 13 条

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