Hepatitis B virus genetic variability and evolution

被引：261

作者：

Kay, Alan

Zoulim, Fabien

机构：

[1] INSERM, U871, Physiopathol Mol Nouveaux Traitements Hepatites V, F-69424 Lyon, France

[2] Univ Lyon 1, Fac Med, IFR62, F-69008 Lyon, France

[3] Hospices Civils Lyon, Hotel Dieu, Serv Hepatol, F-69002 Lyon, France

来源：

VIRUS RESEARCH | 2007年 / 127卷 / 02期

关键词：

HBV; genetics; evolution; serotypes; genotypes; mutations;

D O I：

10.1016/j.virusres.2007.02.021

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hepatitis B virus has been evolving gradually over a long period of time, resulting in a large amount of genetic diversity, despite the constraints imposed by the complex genetic organization of the viral genome. This diversity is partly due to virus/host interactions and partly due to parallel evolution in geographically distinct areas. Recombination also appears to be an important element in HBV evolution. Also, human intervention in the form of mass vaccination and antiviral treatment will reduce the burden of HBV-related liver disease but may also be accelerating evolution of the virus. (c) 2007 Elsevier B.V. All rights reserved.

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页码：164 / 176

页数：13

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