The lymphoproliferation mutation in Fas locally unfolds the Fas death domain

被引:35
作者
Eberstadt, M [1 ]
Huang, BH [1 ]
Olejniczak, ET [1 ]
Fesik, SW [1 ]
机构
[1] ABBOTT LABS,ABBOTT PK,IL 60064
关键词
D O I
10.1038/nsb1297-983
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
NMR studies of the lymphoproliferation mutant (V238N) of the Fas death domain indicate that helix 3 is unfolded. This local structural change abolishes binding to FADD - a protein that interacts with Fas and also contains a death domain - and causes the accumulation of autoreactive T cells.
引用
收藏
页码:983 / 985
页数:3
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