Monitoring photosensitizer concentration by use of a fiber-optic probe with a small source-detector separation

被引：28

作者：

Canpolat, M ^{[1
]}

Mourant, JR ^{[1
]}

机构：

[1] Los Alamos Natl Lab, Biosci Div, Los Alamos, NM 87545 USA

来源：

APPLIED OPTICS | 2000年 / 39卷 / 34期

关键词：

D O I：

10.1364/AO.39.006508

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We present a noninvasive method to track the concentration of photodynamic therapy drugs in real time. The method is based on measurements of backscattered and fluorescent light with a steady-state fluorescence spectrometer. The ratio of the fluorescent light to the scattered light is found to be linearly proportional to the absorption coefficient of the photosensitizer. The fiber-optic probe used for the measurements has a small source-detector separation; therefore the measurements could be performed through the working channel of an endoscope. (C) 2000 Optical Society of America OCIS codes: 170.3890, 170.5180.

引用

页码：6508 / 6514

页数：7

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