The Case for Abandoning Therapeutic Chelation of Copper Ions Alzheimer's Disease

被引：76

作者：

Drew, Simon C. ^{[1
]}

机构：

[1] Univ Melbourne, Royal Melbourne Hosp, Dept Med, Melbourne, Vic, Australia

来源：

FRONTIERS IN NEUROSCIENCE | 2017年 / 11卷

基金：

澳大利亚研究理事会;

关键词：

Alzheimer's disease; beta-amyloid; copper; bioinorganic chemistry; N-truncation; chelator; metals hypothesis; metal homeostasis; AMYLOID-BETA-PEPTIDE; COGNITIVE IMPAIRMENT CONVERSION; INSULIN-DEGRADING ENZYME; SENILE PLAQUE CORES; HUMAN SERUM-ALBUMIN; A-BETA; PRECURSOR PROTEIN; TRANSGENIC MICE; CASCADE HYPOTHESIS; HYDROGEN-PEROXIDE;

D O I：

10.3389/fnins.2017.00317

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The "therapeutic chelation" approach to treating Alzheimer's disease (AD) evolved from the metals hypothesis, with the premise that small molecules can be designed to prevent transition metal-induced amyloid deposition and oxidative stress within the AD brain. Over more than 20 years, countless in vitro studies have been devoted to characterizing metal binding, its effect on A beta aggregation, ROS production, and in vitro toxicity. Despite a lack of evidence for any clinical benefit, the conjecture that therapeutic chelation is an effective approach for treating AD remains widespread. Here, the author plays the devil's advocate, questioning the experimental evidence, the dogma, and the value of therapeutic chelation, with a major focus on copper ions.

引用

页数：11

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