Asymmetric transfer hydrogenation of aromatic ketones catalyzed by the iridium hydride complex under ambient conditions

被引：82

作者：

Chen, JS ^{[1
]}

Li, YY ^{[1
]}

Dong, ZR ^{[1
]}

Li, BZ ^{[1
]}

Gao, JX ^{[1
]}

机构：

[1] Xiamen Univ, Dept Chem, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 45期

基金：

中国国家自然科学基金;

关键词：

iridium hydride complex; chiral ligand; aromatic ketone; asymmetric transfer hydrogenation;

D O I：

10.1016/j.tetlet.2004.09.088

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The chiral Ir catalytic system generated in situ from iridium hydride complex and chiral diaminodiphosphine ligand was employed in asymmetric transfer hydrogenation of aromatic ketones to give the corresponding optically active alcohols, with up to 99% ee in high yield were obtained even when the substrate-to-catalyst molar ratio reached 10000:1. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：8415 / 8418

页数：4

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