Endometrial carcinoma

被引:186
作者
Di Cristofano, Antonio
Ellenson, Lora Hedrick
机构
[1] Fox Chase Canc Ctr, Human Genet Program, Div Populat Sci, Philadelphia, PA 19111 USA
[2] Cornell Univ, Weill Med Coll, Dept Pathol, Div Gynecol Pathol, New York, NY 10021 USA
关键词
endometrioid; serous; molecular genetics; estrogen receptor; PTEN; mouse models; EPIDERMAL-GROWTH-FACTOR; ESTROGEN-RECEPTOR-ALPHA; PAPILLARY SEROUS CARCINOMA; CLEAR-CELL-CARCINOMA; FEMALE REPRODUCTIVE-TRACT; WNT SIGNALING PATHWAY; TUMOR-SUPPRESSOR GENE; FACTOR-I; MICROSATELLITE INSTABILITY; MESSENGER-RNA;
D O I
10.1146/annurev.pathol.2.010506.091905
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Endometrial carcinoma, a common malignancy of the female genital tract, is composed of a number of tumor types with different light-microscopic features, molecular genetic alterations, and prognoses. In addition, hormonal influences significantly impact growth regulatory pathways and interact with genetic alterations in the pathogenesis of at least some types of endometrial carcinorna. These factors have complicated the analyses of endometrial carcinoma, but over the past decades, awareness of the different types of endometrial carcinoma, in addition to careful clinicopathological studies, molecular analyses, and animal studies of the biological underpinnings of the different tumor types, has increased. We present the current understanding of endometrial carcinoma, from a molecular vantage point, highlighting what are presently thought to be the fundamental pathways involved in the development and progression of the major types of endometrial carcinorna.
引用
收藏
页码:57 / 85
页数:29
相关论文
共 151 条
[1]   Insulin-like growth factor 1 is required for G2 progression in the estradiol-induced mitotic cycle [J].
Adesanya, OO ;
Zhou, J ;
Samathanam, C ;
Powell-Braxton, L ;
Bondy, CA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (06) :3287-3291
[2]   ENDOMETRIAL INTRAEPITHELIAL CARCINOMA - A DISTINCTIVE LESION SPECIFICALLY ASSOCIATED WITH TUMORS DISPLAYING SEROUS DIFFERENTIATION [J].
AMBROS, RA ;
SHERMAN, ME ;
ZAHN, CM ;
BITTERMAN, P ;
KURMAN, RJ .
HUMAN PATHOLOGY, 1995, 26 (11) :1260-1267
[3]   Molecular characterization of uterine clear cell carcinoma [J].
An, HJ ;
Logani, S ;
Isacson, C ;
Ellenson, LH .
MODERN PATHOLOGY, 2004, 17 (05) :530-537
[4]   Early uterine serous carcinoma: Clonal origin of extrauterine disease [J].
Baergen, RN ;
Warren, CD ;
Isacson, C ;
Ellenson, LH .
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 2001, 20 (03) :214-219
[5]   Effects of an Igf1 gene null mutation on mouse reproduction [J].
Baker, J ;
Hardy, MP ;
Zhou, J ;
Bondy, C ;
Lupu, F ;
Bellve, AR ;
Efstratiadis, A .
MOLECULAR ENDOCRINOLOGY, 1996, 10 (07) :903-918
[6]   Activation of AKT kinases in cancer: Implications for therapeutic targeting [J].
Bellacosa, A ;
Kumar, CC ;
Di Cristofano, A ;
Testa, JR .
ADVANCES IN CANCER RESEARCH, VOL 94, 2005, 94 :29-+
[7]   A multicentric European study testing the reproducibility of the WHO classification of endometrial hyperplasia with a proposal of a simplified working classification for biopsy and curettage specimens [J].
Bergeron, C ;
Nogales, FF ;
Masseroli, M ;
Abeler, V ;
Duvillard, P ;
Müller-Holzner, E ;
Pickartz, H ;
Wells, M .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1999, 23 (09) :1102-1108
[8]   Risk and prognosis of endometrial cancer after tamoxifen for breast cancer [J].
Bergman, L ;
Beelen, MLR ;
Gallee, MPW ;
Hollema, H ;
Benraadt, J ;
van Leeuwen, FE .
LANCET, 2000, 356 (9233) :881-887
[9]   Estrogen induces a systemic growth factor through an estrogen receptor-alpha-dependent mechanism [J].
Bigsby, RM ;
Caperell-Grant, A ;
Berry, N ;
Nephew, K ;
Lubahn, D .
BIOLOGY OF REPRODUCTION, 2004, 70 (01) :178-183
[10]   The relationship between microsatellite instability and PTEN gene mutations in endometrial cancer [J].
Bilbao, Cristina ;
Rodriguez, German ;
Ramirez, Raquel ;
Falcon, Orlando ;
Leon, Laureano ;
Chirino, Ricardo ;
Rivero, Juan F. ;
Falcon, Orlando, Jr. ;
Diaz-Chico, B. Nicolas ;
Diaz-Chico, Juan C. ;
Perucho, Manuel .
INTERNATIONAL JOURNAL OF CANCER, 2006, 119 (03) :563-570