Novel phenyl nitrogen mustard and half-mustard derivatives of amidino-modified distamycin

被引：25

作者：

Cozzi, P ^{[1
]}

Beria, I ^{[1
]}

Biasoli, G ^{[1
]}

Caldarelli, M ^{[1
]}

Capolongo, L ^{[1
]}

Geroni, C ^{[1
]}

Mongelli, N ^{[1
]}

机构：

[1] Pharmacia & Upjohn Inc, Preclin Res, Therapeut Area Oncol & Immunol, I-20014 Nerviano, Milan, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 23期

关键词：

D O I：

10.1016/S0960-894X(97)10120-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The design, synthesis, and in vitro and in vivo activities of novel benzoyl and cinnamoyl nitrogen mustard and half-mustard derivatives of distamycin A, in which the amidino moiety has been replaced by moieties of different physico-chemical features, are described and structure-activity relationships are discussed. Some amidino-modified derivatives show significant cytotoxicity and antileukemic activity. (C) 1997 Elsevier Science Ltd.

引用

页码：2979 / 2984

页数：6

共 18 条

[1]

BAKER PL, 1981, J ORG CHEM, V46, P2456

[2] TOTAL SYNTHESIS OF DISTAMYCIN-A, AN ANTI-VIRAL ANTIBIOTIC [J].