Further development of raccoon poxvirus-vectored vaccines against plague (Yersinia pestis)

被引：12

作者：

Rocke, Tonie E. ^{[1
]}

Iams, Keith P. ^{[2
]}

Dawe, Sandra ^{[2
]}

Smith, Susan R. ^{[1
]}

Williamson, Judy L. ^{[1
]}

Heisey, Dennis M. ^{[1
]}

Osorio, Jorge E. ^{[2
]}

机构：

[1] USGS BRD, Natl Wildlife Hlth Ctr, Madison, WI 53711 USA

[2] Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Madison, WI 53706 USA

来源：

VACCINE | 2009年 / 28卷 / 02期

关键词：

Raccoon poxvirus; Vaccine; Yersinia pestis; RH: Raccoon poxvirus-vectored vaccines against plague; V-ANTIGEN; FUSION PROTEIN; MICE; GLYCOPROTEIN; SUPPRESSION; CONSUMPTION; INHIBITION; EXPRESSION; PROTECTION; IMMUNITY;

D O I：

10.1016/j.vaccine.2009.10.043

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In previous studies, we demonstrated protection against plague in mice and prairie dogs using a raccoon pox (RCN) virus-vectored vaccine that expressed the F1 capsular antigen of Yersinia pestis. In order to improve vaccine efficacy, we have now constructed additional RCN-plague vaccines containing two different forms of the IcrV(V) gene, including full-length (Vfull) and a truncated form (V307). Mouse challenge studies with Y. pestis strain CO92 showed that vaccination with a combination of RCN-F1 and the truncated V construct (RCN-V307) provided the greatest improvement (P=0.01) in protection against plague over vaccination with RCN-F1 alone. This effect was mediated primarily by anti-F1 and anti-V antibodies and both contributed independently to increased survival of vaccinated mice. Published by Elsevier Ltd.

引用

页码：338 / 344

页数：7

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