Interactions between insulin resistance and insulin secretion in the development of glucose intolerance

被引：280

作者：

Cavaghan, MK

Ehrmann, DA

Polonsky, KS

机构：

[1] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

[2] Univ Chicago, Pritzker Sch Med, Dept Med, Chicago, IL 60637 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2000年 / 106卷 / 03期

关键词：

D O I：

10.1172/JCI10761

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

[No abstract available]

引用

页码：329 / 333

页数：5

共 38 条

[1] Differential effects of overexpressed glucokinase and hexokinase I in isolated islets - Evidence for functional segregation of the high and low K-m enzymes [J].

Becker, TC ;

Noel, RJ ;

Johnson, JH ;

Lynch, RM ;

Hirose, H ;

Tokuyama, Y ;

Bell, GI ;

Newgard, CB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (01) :390-394

[2]

BECKER TC, 1994, J BIOL CHEM, V269, P21234

[3] EFFECTS OF LIPID ON BASAL CARBOHYDRATE-METABOLISM IN NORMAL MEN [J].

BODEN, G ;

JADALI, F .

DIABETES, 1991, 40 (06) :686-692

[4] EFFECTS OF FAT ON INSULIN-STIMULATED CARBOHYDRATE-METABOLISM IN NORMAL MEN [J].

BODEN, G ;

JADALI, F ;

WHITE, J ;

LIANG, Y ;

MOZZOLI, M ;

CHEN, X ;

COLEMAN, E ;

SMITH, C .

JOURNAL OF CLINICAL INVESTIGATION, 1991, 88 (03) :960-966

[5] INSULIN SENSITIVITY AND B-CELL RESPONSIVENESS TO GLUCOSE DURING LATE PREGNANCY IN LEAN AND MODERATELY OBESE WOMEN WITH NORMAL GLUCOSE-TOLERANCE OR MILD GESTATIONAL DIABETES [J].

BUCHANAN, TA ;

METZGER, BE ;

FREINKEL, N ;

BERGMAN, RN .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1990, 162 (04) :1008-1014

[6] Elevated plasma glucose 2 h postchallenge predicts defects in beta-cell function [J].

Byrne, MM ;

Sturis, J ;

Sobel, RJ ;

Polonsky, KS .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1996, 270 (04) :E572-E579

[7] Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation [J].

Carpentier, A ;

Mittelman, SD ;

Lamarche, B ;

Bergman, RN ;

Giacca, A ;

Lewis, GF .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1999, 276 (06) :E1055-E1066

[8]

Cavaghan MK, 1999, DIABETES, V48, pA239

[9] Treatment with the oral antidiabetic agent troglitazone improves beta cell responses to glucose in subjects with impaired glucose tolerance [J].

Cavaghan, MK ;

Ehrmann, DA ;

Byrne, MM ;

Polonsky, KS .

JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (03) :530-537

[10] Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity, and the onset of diabetes [J].

Cockburn, BN ;

Ostrega, DM ;

Sturis, J ;

Kubstrup, C ;

Polonsky, KS ;

Bell, GI .

DIABETES, 1997, 46 (09) :1434-1439

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