Wide genome comparisons reveal the origins of the human X chromosome

被引:66
作者
Kohn, M
Kehrer-Sawatzki, H
Vogel, W
Graves, JAM
Hameister, H [1 ]
机构
[1] Univ Ulm, Dept Human Genet, D-89070 Ulm, Germany
[2] Australian Natl Univ, Res Sch Biol Sci, Comparat Genom Res Grp, Canberra, ACT 2601, Australia
关键词
D O I
10.1016/j.tig.2004.09.008
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The eutherian X chromosome has one of the most conserved gene arrangements in mammals. Although earlier comparisons with distantly related mammalian groups pointed towards separate origins for the short and long arms, much deeper comparisons are now possible using draft sequences of the chicken genome, in combination with genome sequences from pufferfish and zebrafish. This enables surprising new insights into the origins of the mammalian X chromosome.
引用
收藏
页码:598 / 603
页数:6
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