Diabetes mellitus and heart failure: basic mechanisms, clinical features, and therapeutic considerations

被引:32
作者
Giles, TD [1 ]
Sander, GE [1 ]
机构
[1] Louisiana State Univ, Hlth Sci Ctr, Cardiol Sect, New Orleans, LA 70112 USA
关键词
D O I
10.1016/j.ccl.2004.07.002
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The metabolic abnormalities that are associated with diabetes mellitus result in macrovascular and microvascular complications in multiple organ systems; the cardiovascular impact accounts for the greatest morbidity and mortality that are associated with this disease. Heart failure, with reduced or preserved systolic function, is a major complication and arises from the frequent associations with coronary atherosclerosis, hypertension, and a specific heart muscle dysfunction (cardiomyopathy) that occurs independently of coronary artery disease. Hyperglycemia, insulin resistance, and hypertension, together with activation of circulating and tissue renin-angiotensin-aldosterone systems, contribute to structural fibrosis and autonomic neuropathy. It is imperative to identify cardiac abnormalities early in the course of type 1 and type 2 diabetes to allow for early and aggressive intervention to control glucose and blood pressure and to normalize blood lipid profiles.
引用
收藏
页码:553 / +
页数:17
相关论文
共 139 条
[91]   INSULIN RESISTANCE AND HYPERINSULINEMIA IN PATIENTS WITH CHRONIC CONGESTIVE-HEART-FAILURE [J].
PAOLISSO, G ;
DERIU, S ;
MARRAZZO, G ;
VERZA, M ;
VARRICCHIO, M ;
DONOFRIO, F .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1991, 40 (09) :972-977
[92]   Differentiation of the metabolic and vascular effects of insulin in insulin resistance in patients with chronic heart failure [J].
Parsonage, W ;
Hetmanski, D ;
Cowley, A .
AMERICAN JOURNAL OF CARDIOLOGY, 2002, 89 (06) :696-703
[93]   Nonhypoglycemic effects of thiazolidinediones [J].
Parulkar, AA ;
Pendergrass, ML ;
Granda-Ayala, R ;
Lee, TR ;
Fonseca, VA .
ANNALS OF INTERNAL MEDICINE, 2001, 134 (01) :61-71
[94]   A calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease - The International Verapamil-Trandolapril Study (INVEST): A randomized controlled trial [J].
Pepine, CJ ;
Handberg, EM ;
Cooper-Dehoff, RM ;
Marks, RG ;
Kowey, P ;
Messerli, FH ;
Mancia, G ;
Cangiano, JL ;
Garcia-Barreto, D ;
Keltai, M ;
Erdine, S ;
Bristol, HA ;
Kolb, HR ;
Bakris, GL ;
Cohen, JD ;
Parmley, WW .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 290 (21) :2805-2816
[95]   Effects of candesartan on mortality and morbidity in patients with chronic heart failure:: the CHARM-Overall programme [J].
Pfeffer, MA ;
Swedberg, K ;
Granger, CB ;
Held, P ;
McMurray, JJV ;
Michelson, EL ;
Olofsson, B ;
Östergren, J ;
Yusuf, S .
LANCET, 2003, 362 (9386) :759-766
[96]   Editorlal comment - Diabetic cardiomyopathy: The importance of being earliest [J].
Picano, E .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2003, 42 (03) :454-457
[97]  
Piccini Jonathan P., 2004, American Journal of Medicine, V116, p64S
[98]   Two years of intensive glycemic control and left ventricular function in the Veterans Affairs Cooperative Study in Type 2 Diabetes Mellitus (VA CSDM) [J].
Pitale, SU ;
Abraira, C ;
Emanuele, NV ;
McCarren, M ;
Henderson, WG ;
Pacold, I ;
Bushnell, D ;
Colwell, JA ;
Nuttall, FQ ;
Levin, SR ;
Sawin, CT ;
Comstock, JP ;
Silbert, CK .
DIABETES CARE, 2000, 23 (09) :1316-1320
[99]   Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction [J].
Pitt, B ;
Remme, W ;
Zannad, F ;
Neaton, J ;
Martinez, F ;
Roniker, B ;
Bittman, R ;
Hurley, S ;
Kleiman, J ;
Gatlin, M .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (14) :1309-1321
[100]   Insulin, proinsulin, proinsulin:insulin ratio, and the risk of developing type 2 diabetes mellitus in women [J].
Pradhan, AD ;
Manson, JE ;
Meigs, JB ;
Rifai, N ;
Buring, JE ;
Liu, SM ;
Ridker, PM .
AMERICAN JOURNAL OF MEDICINE, 2003, 114 (06) :438-444