Use of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide and isothiazolidin-3-one 1,1 dioxide scaffolds in the design of potent inhibitors of serine proteinases

被引：35

作者：

Kuang, RZ ^{[1
]}

Venkataraman, R ^{[1
]}

Ruan, SM ^{[1
]}

Groutas, WC ^{[1
]}

机构：

[1] Wichita State Univ, Dept Chem, Wichita, KS 67260 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(98)00067-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The attachment of a phosphate leaving group to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide and isothiazolidin-3-one 1,1 dioxide scaffolds was found to yield highly potent, time-dependent inhibitors of human leukocyte elastase (HLE). (C) 1998 Elsevier Science Ltd. All rights reserved.

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收藏

页码：539 / 544

页数：6

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