Mechanisms of homocysteine toxicity in humans

被引：268

作者：

Perla-Kajan, J.

Twardowski, T.

Jakubowski, H.

机构：

[1] Polish Acad Sci, Inst Bioorgan Chem, Poznan, Poland

[2] Univ Med & Dent New Jersey, Sch Med, Newark, NJ 07103 USA

来源：

AMINO ACIDS | 2007年 / 32卷 / 04期

关键词：

homocysteine; homocysteine thiolactone; protein N-homocysteinylation; toxicity; autoantibodies; protein S-homocysteinylation;

D O I：

10.1007/s00726-006-0432-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Homocysteine, a non-protein amino acid, is an important risk factor for ischemic heart disease and stroke in humans. This review provides an overview of homocysteine influence on endothelium function as well as on protein metabolism with a special respect to posttranslational modification of protein with homocysteine thiolactone. Homocysteine is a pro-thrombotic factor, vasodilation impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer. Incorporation of Hcy into protein via disulfide or amide linkages (S-homocysteinylation or N-homocysteinylation) affects protein structure and function. Protein N-homocysteinylation causes cellular toxicity and elicits autoimmune response, which may contribute to atherogenesis.

引用

页码：561 / 572

页数：12

共 95 条

[1]

Abcouwer SF, 2002, INVEST OPHTH VIS SCI, V43, P2791

[2] Plasma homocysteine predicts mortality independently of traditional risk factors and C-reactive protein in patients with angiographically defined coronary artery disease [J].