Associations of circulating C-reactive protein and interleukin-6 with survival in women with and without cancer:: Findings from the British Women's Heart and Health Study

被引:54
作者
Heikkila, Katriina
Ebrahim, Shah
Rumley, Ann
Lowe, Gordon
Lawlor, Debbie A.
机构
[1] Univ Bristol, Dept Social Med, Bristol BS8 2PR, Avon, England
[2] London Sch Hyg & Trop Med, London WC1, England
[3] Univ Glasgow, Div Cardiovasc & Med Sci, Glasgow, Lanark, Scotland
关键词
D O I
10.1158/1055-9965.EPI-07-0093
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Inflammation is associated with worse prognosis and survival in many cancers. Our aim was to investigate the associations of circulating C-reactive protein (CRP) and interleukin-6 (IL-6) concentrations with all-cause mortality in cancer patients and to determine whether any associations were specific to malignancy. Method: We used data from the British Women's Heart and Health Study, a cohort of 4,286 women aged 60 to 79 years. We investigated the associations between CRP, IL-6, and survival in women with and without cancer using Cox regression and assessed the interaction between cancer status and these inflammatory markers to determine whether these associations differed according to cancer status. Results: Elevated CRP and IL-6 were associated with decreased survival in women with cancer [unadjusted hazard ratio per doubling of CRP, 1.22, 95% confidence interval (95% CI), 1.03, 1.46; and per doubling of IL-6, 1.52, 95% CI, 1.25, 1.86] and in women without cancer [CRP: 1.24 (1.12, 1.37); IL-6: 1.53 (1.35, 1.75)]. Adjustment for age, body mass index, physical activity level, socioeconomic position, HRT use, and tobacco smoking did not change these associations. After mutual adjustment, IL-6 but not CRP was independently associated with survival. We found no strong evidence that these associations differed between cancer patients and cancer-free women. Conclusions: Elevated CRP and IL-6 concentrations were similarly associated with an increased risk of death in elderly women with and without cancer. Thus, in this group, these markers are likely to be indicators of non-cancer comorbidities rather than related to the malignancy itself.
引用
收藏
页码:1155 / 1159
页数:5
相关论文
共 19 条
[1]  
Albuquerque K V, 1995, Eur J Surg Oncol, V21, P504, DOI 10.1016/S0748-7983(95)96935-7
[2]   The clinical and prognostic significance of erythrocyte sedimentation rate (ESR), serum interleukin-6 (IL-6) and acute phase protein levels in multiple myeloma [J].
Alexandrakis, MG ;
Passam, FH ;
Ganotakis, ES ;
Sfiridaki, K ;
Xilouri, I ;
Perisinakis, K ;
Kyriakou, DS .
CLINICAL AND LABORATORY HAEMATOLOGY, 2003, 25 (01) :41-46
[3]  
Barber MD, 1999, CLIN EXP IMMUNOL, V117, P425
[4]   Serum interleukin-6 levels reflect the disease status of colorectal cancer [J].
Chung, YC ;
Chang, YF .
JOURNAL OF SURGICAL ONCOLOGY, 2003, 83 (04) :222-226
[5]   An elevated C-reactive protein concentration, prior to surgery, predicts poor cancer-specific survival in patients undergoing resection for gastro-oesophageal cancer [J].
Crumley, A. B. C. ;
McMillan, D. C. ;
McKernan, M. ;
Going, J. J. ;
Shearer, C. J. ;
Stuart, R. C. .
BRITISH JOURNAL OF CANCER, 2006, 94 (11) :1568-1571
[6]   A pilot study of longitudinal serum cytokine and angiogenesis factor levels as markers of therapeutic response and survival in patients with head and neck squamous cell carcinoma [J].
Druzgal, CH ;
Chen, Z ;
Yeh, NT ;
Thomas, GR ;
Ondrey, FG ;
Duffey, DC ;
Vilela, RJ ;
Ende, K ;
McCullagh, L ;
Rudy, SF ;
Muir, C ;
Herscher, LL ;
Morris, JC ;
Albert, PS ;
Van Waes, C .
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2005, 27 (09) :771-784
[7]   Cytokines in pancreatic carcinoma - Correlation with phenotypic characteristics and prognosis [J].
Ebrahimi, B ;
Tucker, SL ;
Li, DH ;
Abbruzzese, JL ;
Kurzrock, R .
CANCER, 2004, 101 (12) :2727-2736
[8]   Interleukin-6 level in patients with colorectal cancer [J].
Esfandi, Farideh ;
Ghobadloo, Shahrokh Mohammadzadeh ;
Basati, Gholam .
CANCER LETTERS, 2006, 244 (01) :76-78
[9]  
HEIKKILA K, 2007, IN PRESS J EPIDEMIOL
[10]   Associations of fibrinogen and C-reactive protein with prevalent and incident coronary heart disease are attenuated by adjustment for confounding factors - British Women's Heart and Health Study [J].
Lawlor, DA ;
Smith, GD ;
Rumley, A ;
Lowe, GDO ;
Ebrahim, S .
THROMBOSIS AND HAEMOSTASIS, 2005, 93 (05) :955-963