共 41 条
Functional characterization of a Trypanosoma brucei TATA-binding protein-related factor points to a universal regulator of transcription in trypanosomes
被引:52
作者:

Ruan, JP
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06536 USA

Arhin, GK
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06536 USA

Ullu, E
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06536 USA

Tschudi, C
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06536 USA
机构:
[1] Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06536 USA
[2] Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06536 USA
[3] Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06536 USA
关键词:
D O I:
10.1128/MCB.24.21.9610-9618.2004
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Transcriptional mechanisms remain poorly understood in trypanosomatid protozoa. In particular, there is no knowledge about the function of basal transcription factors, and there is an apparent rarity of promoters for protein-coding genes transcribed by RNA polymerase (Pol) II. Here we describe a Trypanosoma brucei factor related to the TATA-binding protein (TBP). Although this TBP-related factor (TBP-related factor 4 [TRF4]) has about 31% identity to the TBP core domain, several key residues involved in TATA box binding are not conserved. Depletion of the T. brucei TRF4 (TbTRF4) by RNA interference revealed an essential role in RNA Pol I, II, and III transcription. Using chromatin immunoprecipitation, we further showed that TRF4 is recruited to the Pol I-transcribed procyclic acidic repetitive genes, Poll II-transcribed spliced leader RNA genes, and Pol III-transcribed U-snRNA and 7SL RNA genes, thus supporting a role for TbTRF4 in transcription performed by all three nuclear RNA polymerases. Finally, a search for TRF4 binding sites in the T. brucei genome led to the identification of such sites in the 3' portion of certain protein-coding genes, indicating a unique aspect of Pol II transcription in these organisms.
引用
收藏
页码:9610 / 9618
页数:9
相关论文
共 41 条
[1]
A novel epitope tag system to study protein targeting and organelle biogenesis in Trypanosoma brucei
[J].
Bastin, P
;
Bagherzadeh, A
;
Matthews, KR
;
Gull, K
.
MOLECULAR AND BIOCHEMICAL PARASITOLOGY,
1996, 77 (02)
:235-239

论文数: 引用数:
h-index:
机构:

Bagherzadeh, A
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV MANCHESTER,SCH BIOL SCI,MANCHESTER M13 9PT,LANCS,ENGLAND UNIV MANCHESTER,SCH BIOL SCI,MANCHESTER M13 9PT,LANCS,ENGLAND

Matthews, KR
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV MANCHESTER,SCH BIOL SCI,MANCHESTER M13 9PT,LANCS,ENGLAND UNIV MANCHESTER,SCH BIOL SCI,MANCHESTER M13 9PT,LANCS,ENGLAND

Gull, K
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV MANCHESTER,SCH BIOL SCI,MANCHESTER M13 9PT,LANCS,ENGLAND UNIV MANCHESTER,SCH BIOL SCI,MANCHESTER M13 9PT,LANCS,ENGLAND
[2]
TBP-like factors come into focus
[J].
Berk, AJ
.
CELL,
2000, 103 (01)
:5-8

Berk, AJ
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90095 USA Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90095 USA
[3]
Biochemistry and structural biology of transcription factor IID (TFIID)
[J].
Burley, SK
;
Roeder, RG
.
ANNUAL REVIEW OF BIOCHEMISTRY,
1996, 65
:769-799

Burley, SK
论文数: 0 引用数: 0
h-index: 0
机构: ROCKEFELLER UNIV,HOWARD HUGHES MED INST,NEW YORK,NY 10021

Roeder, RG
论文数: 0 引用数: 0
h-index: 0
机构: ROCKEFELLER UNIV,HOWARD HUGHES MED INST,NEW YORK,NY 10021
[4]
Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs
[J].
Cawley, S
;
Bekiranov, S
;
Ng, HH
;
Kapranov, P
;
Sekinger, EA
;
Kampa, D
;
Piccolboni, A
;
Sementchenko, V
;
Cheng, J
;
Williams, AJ
;
Wheeler, R
;
Wong, B
;
Drenkow, J
;
Yamanaka, M
;
Patel, S
;
Brubaker, S
;
Tammana, H
;
Helt, G
;
Struhl, K
;
Gingeras, TR
.
CELL,
2004, 116 (04)
:499-509

Cawley, S
论文数: 0 引用数: 0
h-index: 0
机构: Affymetrix, Santa Clara, CA 95051 USA

Bekiranov, S
论文数: 0 引用数: 0
h-index: 0
机构: Affymetrix, Santa Clara, CA 95051 USA

Ng, HH
论文数: 0 引用数: 0
h-index: 0
机构: Affymetrix, Santa Clara, CA 95051 USA

Kapranov, P
论文数: 0 引用数: 0
h-index: 0
机构: Affymetrix, Santa Clara, CA 95051 USA

Sekinger, EA
论文数: 0 引用数: 0
h-index: 0
机构: Affymetrix, Santa Clara, CA 95051 USA

Kampa, D
论文数: 0 引用数: 0
h-index: 0
机构: Affymetrix, Santa Clara, CA 95051 USA

Piccolboni, A
论文数: 0 引用数: 0
h-index: 0
机构: Affymetrix, Santa Clara, CA 95051 USA

Sementchenko, V
论文数: 0 引用数: 0
h-index: 0
机构: Affymetrix, Santa Clara, CA 95051 USA

Cheng, J
论文数: 0 引用数: 0
h-index: 0
机构: Affymetrix, Santa Clara, CA 95051 USA

Williams, AJ
论文数: 0 引用数: 0
h-index: 0
机构: Affymetrix, Santa Clara, CA 95051 USA

Wheeler, R
论文数: 0 引用数: 0
h-index: 0
机构: Affymetrix, Santa Clara, CA 95051 USA

Wong, B
论文数: 0 引用数: 0
h-index: 0
机构: Affymetrix, Santa Clara, CA 95051 USA

Drenkow, J
论文数: 0 引用数: 0
h-index: 0
机构: Affymetrix, Santa Clara, CA 95051 USA

Yamanaka, M
论文数: 0 引用数: 0
h-index: 0
机构: Affymetrix, Santa Clara, CA 95051 USA

Patel, S
论文数: 0 引用数: 0
h-index: 0
机构: Affymetrix, Santa Clara, CA 95051 USA

Brubaker, S
论文数: 0 引用数: 0
h-index: 0
机构: Affymetrix, Santa Clara, CA 95051 USA

Tammana, H
论文数: 0 引用数: 0
h-index: 0
机构: Affymetrix, Santa Clara, CA 95051 USA

Helt, G
论文数: 0 引用数: 0
h-index: 0
机构: Affymetrix, Santa Clara, CA 95051 USA

Struhl, K
论文数: 0 引用数: 0
h-index: 0
机构: Affymetrix, Santa Clara, CA 95051 USA

Gingeras, TR
论文数: 0 引用数: 0
h-index: 0
机构: Affymetrix, Santa Clara, CA 95051 USA
[5]
Life without transcriptional control? From fly to man and back again
[J].
Clayton, CE
.
EMBO JOURNAL,
2002, 21 (08)
:1881-1888

Clayton, CE
论文数: 0 引用数: 0
h-index: 0
机构:
ZMBH, D-69120 Heidelberg, Germany ZMBH, D-69120 Heidelberg, Germany
[6]
TBP-like factor is required for embryonic RNA polymerase II transcription in C-elegans
[J].
Dantonel, JC
;
Quintin, S
;
Lakatos, L
;
Labouesse, M
;
Tora, L
.
MOLECULAR CELL,
2000, 6 (03)
:715-722

Dantonel, JC
论文数: 0 引用数: 0
h-index: 0
机构:
ULP, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch, France ULP, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch, France

Quintin, S
论文数: 0 引用数: 0
h-index: 0
机构:
ULP, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch, France ULP, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch, France

Lakatos, L
论文数: 0 引用数: 0
h-index: 0
机构:
ULP, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch, France ULP, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch, France

Labouesse, M
论文数: 0 引用数: 0
h-index: 0
机构:
ULP, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch, France ULP, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch, France

Tora, L
论文数: 0 引用数: 0
h-index: 0
机构:
ULP, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch, France ULP, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch, France
[7]
The TBP-like factor: an alternative transcription factor in Metazoa?
[J].
Dantonel, JC
;
Wurtz, JM
;
Poch, O
;
Moras, D
;
Tora, L
.
TRENDS IN BIOCHEMICAL SCIENCES,
1999, 24 (09)
:335-339

Dantonel, JC
论文数: 0 引用数: 0
h-index: 0
机构:
ULP, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire,CU Strasbourg, F-67404 Illkirch, France ULP, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire,CU Strasbourg, F-67404 Illkirch, France

Wurtz, JM
论文数: 0 引用数: 0
h-index: 0
机构:
ULP, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire,CU Strasbourg, F-67404 Illkirch, France ULP, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire,CU Strasbourg, F-67404 Illkirch, France

Poch, O
论文数: 0 引用数: 0
h-index: 0
机构:
ULP, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire,CU Strasbourg, F-67404 Illkirch, France ULP, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire,CU Strasbourg, F-67404 Illkirch, France

Moras, D
论文数: 0 引用数: 0
h-index: 0
机构:
ULP, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire,CU Strasbourg, F-67404 Illkirch, France ULP, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire,CU Strasbourg, F-67404 Illkirch, France

Tora, L
论文数: 0 引用数: 0
h-index: 0
机构:
ULP, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire,CU Strasbourg, F-67404 Illkirch, France ULP, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire,CU Strasbourg, F-67404 Illkirch, France
[8]
RNA polymerase II-dependent transcription in trypanosomes is associated with a SNAP complex-like transcription factor
[J].
Das, A
;
Bellofatto, V
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2003, 100 (01)
:80-85

Das, A
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med & Dent New Jersey, New Jersey Med Sch, Int Ctr Publ Hlth, Dept Microbiol & Mol Genet, Newark, NJ 07103 USA Univ Med & Dent New Jersey, New Jersey Med Sch, Int Ctr Publ Hlth, Dept Microbiol & Mol Genet, Newark, NJ 07103 USA

Bellofatto, V
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med & Dent New Jersey, New Jersey Med Sch, Int Ctr Publ Hlth, Dept Microbiol & Mol Genet, Newark, NJ 07103 USA Univ Med & Dent New Jersey, New Jersey Med Sch, Int Ctr Publ Hlth, Dept Microbiol & Mol Genet, Newark, NJ 07103 USA
[9]
The sequence and analysis of Trypanosoma brucei chromosome II
[J].
El-Sayed, NMA
;
Ghedin, E
;
Song, JM
;
MacLeod, A
;
Bringaud, F
;
Larkin, C
;
Wanless, D
;
Peterson, J
;
Hou, LH
;
Taylor, S
;
Tweedie, A
;
Biteau, N
;
Khalak, HG
;
Lin, XY
;
Mason, T
;
Hannick, L
;
Caler, E
;
Blandin, G
;
Bartholomeu, D
;
Simpson, AJ
;
Kaul, S
;
Zhao, H
;
Pai, G
;
Van Aken, S
;
Utterback, T
;
Haas, B
;
Koo, HL
;
Umayam, L
;
Suh, B
;
Gerrard, C
;
Leech, V
;
Qi, R
;
Zhou, SG
;
Schwartz, D
;
Feldblyum, T
;
Salzberg, S
;
Tait, A
;
Turner, CMR
;
Ullu, E
;
White, O
;
Melville, S
;
Adams, MD
;
Fraser, CM
;
Donelson, JE
.
NUCLEIC ACIDS RESEARCH,
2003, 31 (16)
:4856-4863

El-Sayed, NMA
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Ghedin, E
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Song, JM
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

MacLeod, A
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Bringaud, F
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Larkin, C
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Wanless, D
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Peterson, J
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Hou, LH
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Taylor, S
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Tweedie, A
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Biteau, N
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Khalak, HG
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Lin, XY
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Mason, T
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Hannick, L
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Caler, E
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Blandin, G
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Bartholomeu, D
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Simpson, AJ
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Kaul, S
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Zhao, H
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Pai, G
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Van Aken, S
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Utterback, T
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Haas, B
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Koo, HL
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Umayam, L
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Suh, B
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Gerrard, C
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Leech, V
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Qi, R
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Zhou, SG
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Schwartz, D
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Feldblyum, T
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Salzberg, S
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Tait, A
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Turner, CMR
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Ullu, E
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

White, O
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Melville, S
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Adams, MD
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Fraser, CM
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA

Donelson, JE
论文数: 0 引用数: 0
h-index: 0
机构: Inst Genom Res, Rockville, MD 20850 USA
[10]
RNA-POLYMERASE III-MEDIATED TRANSCRIPTION OF THE TRYPANOSOME U2 SMALL NUCLEAR-RNA GENE IS CONTROLLED BY BOTH INTRAGENIC AND EXTRAGENIC REGULATORY ELEMENTS
[J].
FANTONI, A
;
DARE, AO
;
TSCHUDI, C
.
MOLECULAR AND CELLULAR BIOLOGY,
1994, 14 (03)
:2021-2028

FANTONI, A
论文数: 0 引用数: 0
h-index: 0
机构:
YALE UNIV,SCH MED,DEPT INTERNAL MED,INFECT DIS SECT,NEW HAVEN,CT 06520 YALE UNIV,SCH MED,DEPT INTERNAL MED,INFECT DIS SECT,NEW HAVEN,CT 06520

DARE, AO
论文数: 0 引用数: 0
h-index: 0
机构:
YALE UNIV,SCH MED,DEPT INTERNAL MED,INFECT DIS SECT,NEW HAVEN,CT 06520 YALE UNIV,SCH MED,DEPT INTERNAL MED,INFECT DIS SECT,NEW HAVEN,CT 06520

TSCHUDI, C
论文数: 0 引用数: 0
h-index: 0
机构:
YALE UNIV,SCH MED,DEPT INTERNAL MED,INFECT DIS SECT,NEW HAVEN,CT 06520 YALE UNIV,SCH MED,DEPT INTERNAL MED,INFECT DIS SECT,NEW HAVEN,CT 06520