Treatment of solid tumours in children with tumour-lysate-pulsed dendritic cells

被引：98

作者：

Geiger, J ^{[1
]}

Hutchinson, R

Hohenkirk, L

McKenna, E

Chang, A

Mulé, J

机构：

[1] Univ Michigan, Sch Med, Dept Surg, Pediat Surg Sect, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Dept Pediat, Ann Arbor, MI 48109 USA

来源：

LANCET | 2000年 / 356卷 / 9236期

关键词：

D O I：

10.1016/S0140-6736(00)02762-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Dendritic cells are potent stimulators of antigen-specific immune responses, including antitumour responses. We explored the use of tumour-lysate-pulsed dendritic cells in children with relapsed solid tumours. Dendritic cell treatment in children was feasible and apparently not toxic. The treatment was able to produce significant tumour regression in a child with metatstatic fibrosarcoma.

引用

页码：1163 / 1165

页数：3

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