Tributylmagnesium ate complex-mediated bromine-magnesium exchange of bromoquinolines:: a convenient access to functionalized quinolines

被引：70

作者：

Dumouchel, S ^{[1
]}

Mongin, F ^{[1
]}

Trécourt, F ^{[1
]}

Quéguiner, G ^{[1
]}

机构：

[1] IRCOF, UMR 6014, Lab Chim Organ Fine & Heterocycl, F-76131 Mont St Aignan, France

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 10期

关键词：

quinoline; Grignard reagents; exchange reaction; ate complexes;

D O I：

10.1016/S0040-4039(03)00183-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-, 3- and 4-bromoquinolines were converted to the corresponding lithium tri(quinolyl)magnesates at -10degreesC by treatment with Bu3MgLi in THF or toluene. The resulting organomagnesium derivatives were quenched by various electrophiles to afford functionalized quinolines. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：2033 / 2035

页数：3

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