Dietary intake of B-vitamins, polymorphisms in thymidylate synthase and serine hydroxymethyltransferase 1, and colorectal adenoma risk: A Dutch case-control study

被引：14

作者：

van den Donk, Maureen ^{[1
]}

Visker, Marleen H. P. W. ^{[1
]}

Harryvan, Jan L. ^{[1
]}

Kok, Frans J. ^{[1
]}

Kampman, Ellen ^{[1
]}

机构：

[1] Univ Wageningen & Res Ctr, Div Human Nutr, NL-6700 EV Wageningen, Netherlands

来源：

CANCER LETTERS | 2007年 / 250卷 / 01期

关键词：

vitamin B complex; colorectal neoplasms; thymidylate synthase; serine hydroxymethyltransferase;

D O I：

10.1016/j.canlet.2006.10.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Thymidylate synthase and serine hydroxymethyltransferase are involved in folate metabolism. In a case-control study, including 768 cases and 709 controls, we investigated the associations between colorectal adenomas and TS tandem repeat and SHMT1 C1420T polymorphisms, and the interplay with B-vitamins. The polymorphisms were not associated with adenomas, but there was a borderline significant interaction between TS genotype and vitamin B6: the association between vitamin B6 and adenomas seemed positive in TS3R/3R individuals, but inverse in TS 2R/2R individuals. This study does not provide evidence for a role of SHMT1 genotype in adenoma occurrence. Future research has to indicate whether the TS-B6 interplay is a real effect or a chance finding. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：146 / 153

页数：8

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