Heritability of menopausal age in mothers and daughters

被引：105

作者：

van Asselt, KM ^{[1
]}

Kok, HS ^{[1
]}

Pearson, PL ^{[1
]}

Dubas, JS ^{[1
]}

Peeters, PHM ^{[1
]}

Velde, ERT ^{[1
]}

van Noord, PAH ^{[1
]}

机构：

[1] Univ Utrecht, Med Ctr, Julius Ctr Hlth Sci & Primary Care, NL-3508 Utrecht, Netherlands

来源：

FERTILITY AND STERILITY | 2004年 / 82卷 / 05期

关键词：

menopause; heritability; genetics;

D O I：

10.1016/j.fertnstert.2004.04.047

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To determine the heritability of age at natural menopause from mother-daughter pairs. Design: Two-generation families were selected to study heritability of menopausal age. Setting: Subjects were drawn from a population-based study. Patient(s): One hundred sixty-four mother-daughter pairs with a natural menopausal age. Intervention(s): None. Main Outcome Measure(s): The heritability of age at natural menopause estimated by a random-effects model. Result(s): A heritability of 44% (95% confidence interval, 36%, 50%) was estimated. Conclusion(s): This study confirms that heritable components largely determine the natural age at menopause. Reasons for the differences between heritability estimates based on sibling pairs and parent-child comparisons are discussed. (C) 2004 by American Society for Reproductive Medicine.

引用

页码：1348 / 1351

页数：4

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