Lactococcus lactis as a Cell Factory for Delivery of Therapeutic Proteins

被引：55

作者：

Bahey-El-Din, Mohammed ^{[1
,2
,3
]}

Gahan, Cormac G. M. ^{[2
,3
,4
]}

Griffin, Brendan T. ^{[2
]}

机构：

[1] Univ Alexandria, Fac Pharm, Dept Pharmaceut Microbiol, Alexandria, Egypt

[2] Univ Coll Cork, Sch Pharm, Cork, Ireland

[3] Univ Coll Cork, Dept Microbiol, Cork, Ireland

[4] Univ Coll Cork, Alimentary Pharmabiot Ctr, Cork, Ireland

来源：

CURRENT GENE THERAPY | 2010年 / 10卷 / 01期

关键词：

Lactococcus; vaccine; therapeutic protein; vector; delivery; immunomodulation; IBD; COMPLETE GENOME SEQUENCE; CYST WALL PROTEIN-2; IMMUNE-RESPONSE; MUCOSAL DELIVERY; IMMUNOMODULATORY PROTEIN; INTRANASAL IMMUNIZATION; ORAL IMMUNIZATION; ACID BACTERIA; GENE-THERAPY; LING ZHI-8;

D O I：

10.2174/156652310790945557

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The food-grade bacterium Lactococcus lactis has been extensively investigated during the last two decades as a delivery vector for therapeutic proteins, DNA and vaccine antigens. The bacterium represents a safe, genetically tractable vector capable of producing heterologous therapeutic proteins at mucosal sites. Here we review recent work in which recombinant L. lactis strains have been exploited as agents to treat inflammatory bowel disease, allergy and cancer. We also describe the ability of L. lactis to deliver proteins with adjuvant potential, vaccines and DNA and discuss the therapeutic possibilities of this approach.

引用

页码：34 / 45

页数：12

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