Changes in the morphology of sympathetic preganglionic neurons parallel the development of autonomic dysreflexia after spinal cord injury in rats

被引：49

作者：

Krenz, NR ^{[1
]}

Weaver, LC ^{[1
]}

机构：

[1] Univ Western Ontario, Neurosci Program, London, ON N6A 3K7, Canada

来源：

NEUROSCIENCE LETTERS | 1998年 / 243卷 / 1-3期

基金：

英国医学研究理事会;

关键词：

sympathetic preganglionic neurons; spinal cord injury; autonomic dysreflexia; regeneration; cholera toxin B subunit;

D O I：

10.1016/S0304-3940(98)00101-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Following spinal cord transection (SCT), sensory input to the spinal cord causes increases in arterial pressure that are small in rats 1 week after SCT, but become large and well established by 2 weeks. Moreover, sympathetic preganglionic neurons (SPNs) undergo atrophy by 1 week after SCT, and regeneration of these neurons may be an important factor in the etiology of this autonomic dysreflexia. Therefore, we examined the morphology of SPNs 2 weeks after SCT using retrograde transport of the cholera toxin subunit B. The dendritic arbors of SPNs were re-established by 2 weeks after SCT. This regeneration parallels the time course of the development of autonomic dysreflexia after cord injury in the rat, and may play a role in initiating this disorder. (C) 1998 Elsevier Science Ireland Ltd.

引用

页码：61 / 64

页数：4

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