HLA class II DNA polymorphism in a Moroccan population from the Souss, Agadir area

被引:90
作者
Izaabel, H
Garchon, HJ
Caillat-Zucman, S
Beaurain, G
Akhayat, O
Bach, JF
Sanchez-Mazas, A
机构
[1] Univ Geneva, Dept Anthropol, Lab Genet & Biometry, CH-1227 Geneva, Switzerland
[2] Univ Geneva, Dept Ecol, Lab Genet & Biometry, CH-1227 Geneva, Switzerland
[3] Univ Ibnou Zohr, Cellular & Mol Biol Lab, Agadir, Morocco
[4] Hop Necker Enfants Malad, Lab INSERM U25, Paris, France
来源
TISSUE ANTIGENS | 1998年 / 51卷 / 01期
关键词
anthropology; HLA class II; Morocco; North Africa; PCR-SSO; population genetics;
D O I
10.1111/j.1399-0039.1998.tb02954.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
HLA DRB1, DQA1 and DQB1 polymorphisms were analyzed by PCR-SSO typing in a sample of the Moroccan population from Souss. Uneven allelic frequency distributions are observed at each locus, with particularly high frequencies for DRB1*0701, DRB1*0301, DQA1*0501, DQA1*0201, and DQB1*0201. Only three haplotypes (DRB1*0701-DQA1*0201-DQB1*0201, DRB1*0301-DQA1*0501-DQB1*0201 and DRB1*11-DQA1*0501-DQB1*0301) account for nearly 50% of the total gene frequencies. A genetic distance analysis reveals that the Moroccan population is close to the Spanish and the Algerians, who live in geographically neighboring areas. However, the Souss population is also characterized by a lower level of genetic diversity compared to other African and European populations from the Mediterranean area. This may be the result of a rapid genetic drift due to their likely geographical and/or cultural isolation.
引用
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页码:106 / 110
页数:5
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