Rho family proteins in cell adhesion and cell migration

被引：198

作者：

Evers, EE ^{[1
]}

Zondag, GCM ^{[1
]}

Malliri, A ^{[1
]}

Price, LS ^{[1
]}

ten Klooster, JP ^{[1
]}

van der Kammen, RA ^{[1
]}

Collard, JG ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Cell Biol, NL-1066 CX Amsterdam, Netherlands

来源：

EUROPEAN JOURNAL OF CANCER | 2000年 / 36卷 / 10期

关键词：

Rac; Rho; adherens junctions; E-cadherin; cell migration; Tiam1;

D O I：

10.1016/S0959-8049(00)00091-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cell migration and the regulation of cadherin-mediated homotypic cell-cell interactions are critical events during development, morphogenesis and wound healing. Aberrations in signalling pathways involved in the regulation of cell migration and cadherin-mediated cell-cell adhesion contribute to tumour invasion and metastasis. The rho family proteins, including cdc42, racl and rhoA, regulate signalling pathways that mediate the distinct actin cytoskeleton changes required for both cellular motility and cell-cell adhesion. Recent studies indicate that rac directly influences rho activity at the GTPase level and that the reciprocal balance between rac and rho activity can determine epithelial or mesenchymal cell morphology and migratory behaviour of epithelial (tumour) cells. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1269 / 1274

页数：6

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