The pig as an experimental animal model of percutaneous permeation in man: Qualitative and quantitative observations - An overview

被引：311

作者：

Simon, GA ^{[1
]}

Maibach, HI ^{[1
]}

机构：

[1] UCSF, Sch Med, Dept Dermatol, San Francisco, CA USA

来源：

SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY | 2000年 / 13卷 / 05期

关键词：

skin permeation; animal model; pig;

D O I：

10.1159/000029928

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The pig has been a well-recognized experimental animal in biomedical research for many centuries. Physiological and anatomical similarities between man and pig made this animal a good model for man in many research areas. Pharmacological and toxicological research on the skin is often based on knowledge of skin absorption and percutaneous permeation. Anatomical, physiological and biochemical similarities are cited and various uses of the pig as a model for man in the investigation of skin permeation are reviewed. Further, several isolated organ models are reviewed. The importance of full details of the experimental animal, namely its age, sex, breed, size (weight) and body region, is emphasized. Copyright (C) 2000 S. Karger AG, Basel.

引用

页码：229 / 234

页数：6

共 59 条

[1]

BAHR KH, 1972, RHEUMAFORSCHUNG, V31, P99

[2]

Bartek M. J., 1975, Animal models in dermatology,, P103

[3] SKIN PERMEABILITY IN-VIVO - COMPARISON IN RAT, RABBIT, PIG AND MAN [J].