Alcohol inversion of 17 beta steroids

被引：30

作者：

Dodge, JA

Lugar, CW

机构：

[1] Lilly Research Laboratories, Eli Lilly and Company, Indianapolis

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 01期

关键词：

MITSUNOBU REACTION;

D O I：

10.1016/0960-894X(95)00559-C

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Inversion of 17 beta-steroids has been accomplished using a modified Mitsunobu protocol in which 4-nitrobenzoic acid is employed as the acidic component. Excellent yields of inverted product were obtained for a number of representative steroid families including estrogens, equilenins, and androgens. Application of this methodology to the synthesis of 17 alpha-dihydroequilenin is described.

引用

页码：1 / 2

页数：2

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