Somatic mutations of EGFR in colorectal cancers and glioblastomas

被引:250
作者
Barber, TD [1 ]
Vogelstein, B
Kinzler, KW
Velculescu, VE
机构
[1] Howard Hughes Med Inst, Baltimore, MD 21231 USA
[2] Johns Hopkins, Sidney Kimmel Canc Ctr, Baltimore, MD 21231 USA
关键词
D O I
10.1056/NEJM200412303512724
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:2883 / 2883
页数:1
相关论文
共 5 条
[1]   Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer [J].
Cunningham, D ;
Humblet, Y ;
Siena, S ;
Khayat, D ;
Bleiberg, H ;
Santoro, A ;
Bets, D ;
Mueser, M ;
Harstrick, A ;
Verslype, C ;
Chau, I ;
Van Cutsem, E .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (04) :337-345
[2]   Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib [J].
Lynch, TJ ;
Bell, DW ;
Sordella, R ;
Gurubhagavatula, S ;
Okimoto, RA ;
Brannigan, BW ;
Harris, PL ;
Haserlat, SM ;
Supko, JG ;
Haluska, FG ;
Louis, DN ;
Christiani, DC ;
Settleman, J ;
Haber, DA .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (21) :2129-2139
[3]   EGFR mutations in lung cancer:: Correlation with clinical response to gefitinib therapy [J].
Paez, JG ;
Jänne, PA ;
Lee, JC ;
Tracy, S ;
Greulich, H ;
Gabriel, S ;
Herman, P ;
Kaye, FJ ;
Lindeman, N ;
Boggon, TJ ;
Naoki, K ;
Sasaki, H ;
Fujii, Y ;
Eck, MJ ;
Sellers, WR ;
Johnson, BE ;
Meyerson, M .
SCIENCE, 2004, 304 (5676) :1497-1500
[4]  
Rasheed B K, 1999, Curr Opin Oncol, V11, P162
[5]   Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor [J].
Saltz, LB ;
Meropol, NJ ;
Loehrer, PJ ;
Needle, MN ;
Kopit, J ;
Mayer, RJ .
JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (07) :1201-1208