Rho family GTPases: more than simple switches

被引：196

作者：

Symons, M

Settleman, J

机构：

[1] Picower Inst Med Res, Manhasset, NY 11030 USA

[2] Harvard Univ, Sch Med, MGH Canc Ctr, Charlestown, MA 02129 USA

来源：

TRENDS IN CELL BIOLOGY | 2000年 / 10卷 / 10期

关键词：

D O I：

10.1016/S0962-8924(00)01832-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Rho family GTPases control a large variety of biological processes. Cycling of Rho proteins between the GDP-bound and the GTP-bound state is controlled by several classes of regulatory proteins. In this review, we discuss the signal-transduction mechanisms that control these regulators. We will emphasize the subcellular localization of Rho GTPases and their regulator), proteins and the role of GTP hydrolysis in signal transmission.

引用

页码：415 / 419

页数：5

共 47 条

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