Chemosensory event-related potentials change with age

被引：100

作者：

Hummel, T

Barz, S

Pauli, E

Kobal, G

机构：

[1] Univ Erlangen Nurnberg, Dept Expt & Clin Pharmacol & Toxicol, D-91054 Erlangen, Germany

[2] Univ Erlangen Nurnberg, Dept Neurol, D-91054 Erlangen, Germany

[3] Univ Dresden, Dept Otolaryngol, D-01307 Dresden, Germany

来源：

EVOKED POTENTIALS-ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY | 1998年 / 108卷 / 02期

关键词：

olfaction; nociception; electrophysiology;

D O I：

10.1016/S0168-5597(97)00074-9

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The study examined age-related changes in the perception of olfactory and trigeminal chemical stimuli using chemosensory event-related potentials (CSERP). Three groups of healthy volunteers, each comprised of 8 men and 8 women, were tested (age ranges 15-34, 35-54, and 55-74 years). Subjects underwent extensive psychological testing focusing on impairments of memory and attention. In addition, odor identification and discrimination ability was evaluated, as well as detection threshold sensitivity for two odorants. Odor discrimination scores exhibited a significant age-related decrease. Significant age-related changes were also observed for CSERP N1P2 and P2 amplitudes, and for the N1 peak latency. The age-related decrease of CSERP amplitudes appeared to follow a different time course for responses to trigeminal and olfactory stimulants. (C) 1998 Elsevier Science Ireland Ltd.

引用

页码：208 / 217

页数：10

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