Poly (D,L-Lactide) glycolide polymer microsphere entrapped tetanus toxoid: Safety evaluation in Wistar rats

被引：9

作者：

Chaudhury, MR ^{[1
]}

Sharma, K ^{[1
]}

Giri, DK ^{[1
]}

机构：

[1] NATL INST IMMUNOL,NEW DELHI 67,INDIA

来源：

HUMAN & EXPERIMENTAL TOXICOLOGY | 1996年 / 15卷 / 03期

关键词：

biodegradable polymer; tetanus toxoid; vaccine; toxicity;

D O I：

10.1177/096032719601500303

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

A vaccine preparation consisting of tetanus toroid (TT) encapsulated in biodegradable poly (D,L-Lactide) glycolide polymer has been developed. The toxicity of the preparation was evaluated in adult male and female Wistar rats injected IM with 20, 100 and 200 Lf tetanus toroid, in polymer in 0.5 ml vehicle. No adverse effect of the vaccine could be seen, except for a granulomatous reaction at the site of injection. The vaccine was considered safe based on the findings in rats of both sexes.

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收藏

页码：205 / 207

页数：3

相关论文

共 14 条

[1] BIODEGRADABLE MICROSPHERES AS CONTROLLED-RELEASE TETANUS TOXOID DELIVERY SYSTEMS [J].

ALONSO, MJ ;

GUPTA, RK ;

MIN, C ;

SIBER, GR ;

LANGER, R .

VACCINE, 1994, 12 (04) :299-306

[2] BIODEGRADABLE AND BIOCOMPATIBLE POLY(DL-LACTIDE-CO-GLYCOLIDE) MICROSPHERES AS AN ADJUVANT FOR STAPHYLOCOCCAL ENTEROTOXIN-B TOXOID WHICH ENHANCES THE LEVEL OF TOXIN-NEUTRALIZING ANTIBODIES [J].

ELDRIDGE, JH ;

STAAS, JK ;

MEULBROEK, JA ;

TICE, TR ;

GILLEY, RM .

INFECTION AND IMMUNITY, 1991, 59 (09) :2978-2986

[3] CONTROLLED VACCINE RELEASE IN THE GUT-ASSOCIATED LYMPHOID-TISSUES .1. ORALLY-ADMINISTERED BIODEGRADABLE MICROSPHERES TARGET THE PEYERS PATCHES [J].

ELDRIDGE, JH ;

HAMMOND, CJ ;

MEULBROEK, JA ;

STAAS, JK ;

GILLEY, RM ;

TICE, TR .

JOURNAL OF CONTROLLED RELEASE, 1990, 11 (1-3) :205-214

[4] PARAMETERS AFFECTING THE IMMUNOGENICITY OF MICROENCAPSULATED TETANUS TOXOID [J].

ESPARZA, I ;

KISSEL, T .

VACCINE, 1992, 10 (10) :714-720

[5]

GILLESPIE G, 1988, CAN REV COMP LIT, V15, P123

[6] CONTROLLED RELEASE OF INTERLEUKIN-2 FROM BIODEGRADABLE MICROSPHERES [J].

HORA, MS ;

RANA, RK ;

NUNBERG, JH ;

TICE, TR ;

GILLEY, RM ;

HUDSON, ME .

BIO-TECHNOLOGY, 1990, 8 (08) :755-758

[7] SINGLE-STEP IMMUNIZATION USING A CONTROLLED RELEASE, BIODEGRADABLE POLYMER WITH SUSTAINED ADJUVANT ACTIVITY [J].

KOHN, J ;

NIEMI, SM ;

ALBERT, EC ;

MURPHY, JC ;

LANGER, R ;

FOX, JG .

JOURNAL OF IMMUNOLOGICAL METHODS, 1986, 95 (01) :31-38

[8]

LANGER R, 1981, METHOD ENZYMOL, V73, P56

[9]

OHAGAN DT, 1991, IMMUNOLOGY, V73, P239

[10] SINGLE-STEP IMMUNIZATION BY SUSTAINED ANTIGEN RELEASE [J].

PREIS, I ;

LANGER, RS .

JOURNAL OF IMMUNOLOGICAL METHODS, 1979, 28 (1-2) :193-197