A new key in breast cancer metastasis

被引：40

作者：

Benovic, JL ^{[1
]}

Marchese, A

机构：

[1] Thomas Jefferson Univ, Kimmel Canc Ctr, Dept Microbiol & Immunol, Philadelphia, PA 19107 USA

[2] Loyola Univ, Dept Pharmacol, Maywood, IL 60153 USA

来源：

CANCER CELL | 2004年 / 6卷 / 05期

关键词：

D O I：

10.1016/j.ccr.2004.10.017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Unlocking the mysteries of cell metastasis, a major cause of cancer mortality, is essential in the development of novel therapies. In this issue of Cancer Cell, Li et al. (2004) identify a link between HER2 and CXCR4, two receptors previously implicated in breast cancer progression and metastasis. HER2 enhances the expression of CXCR4 by stimulating CXCR4 translation and attenuating CXCR4 degradation. Importantly, coexpression of HER2 and CXCR4 occurs in similar to22% of human breast tumors and correlates with poor survival of breast cancer patients.

引用

页码：429 / 430

页数：2

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