Bartter syndrome and focal segmental glomerulosclerosis: a possible link between two diseases

被引：32

作者：

Su, IH

Frank, R

Gauthier, BG

Valderrama, E

Simon, DB

Lifton, RP

Trachtman, H

机构：

[1] Albert Einstein Coll Med, N Shore LIJ Hlth Syst, Schneider Childrens Hosp, Div Pediat Nephrol, New Hyde Park, NY 11040 USA

[2] Albert Einstein Coll Med, N Shore LIJ Hlth Syst, Schneider Childrens Hosp, Dept Pathol, New Hyde Park, NY 11040 USA

[3] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06510 USA

来源：

PEDIATRIC NEPHROLOGY | 2000年 / 14卷 / 10-11期

关键词：

Bartter syndrome; focal segmental glomerulosclerosis;

D O I：

10.1007/s004670050054

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We describe a patient with signs and symptoms of classic Bartter syndrome. The patient tested negative for all known genetic abnormalities associated with this tubular disorder. Proteinuria was found within 1 year after the diagnosis of Bartter syndrome. A renal biopsy performed 6 months later, when her kidney function was normal, revealed focal segmental glomerulosclerosis (FSGS). We propose a link between stimulation of the renin-angiotensin system and sclerotic changes in the glomerulus. This lesion may explain previous reports of kidney failure in patients with Bartter syndrome.

引用

页码：970 / 972

页数：3

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