TEM-72, a new extended-spectrum β-lactamase detected in Proteus mirabilis and Morganella morganii in Italy

被引：30

作者：

Perilli, M

Segatore, B

De Massis, MR

Riccio, ML

Bianchi, C

Zollo, A

Rossolini, GM

Amicosante, G

机构：

[1] Univ Aquila, Cattedra Enzimol, Dipartimento Sci & Tecnol Biomed, I-67100 Laquila, Italy

[2] Univ Siena, Dipartimento Biol Mol, Sez Microbiol, I-53100 Siena, Italy

[3] Wyeth Lederle Italia SpA, Dipartimento Med, Aprilia, Italy

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 09期

关键词：

D O I：

10.1128/AAC.44.9.2537-2539.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

new natural TEM-2 derivative, named TEM-72, was identified in a Proteus mirabilis strain and in a Morganella morganii strain isolated in Italy in 1999, Compared to TEM-1, TEM-72 contains the following amino acid substitutions: Q39K M182T, G238S, and E240K. Kinetic analysis showed that TEM-72 exhibits an extended-spectrum activity, including activity against oxyimino-cephalosporins and aztreonam, Expression of bla(TEM-72) in Escherichia coli was capable of decreasing the host susceptibility to the above drugs.

引用

收藏

页码：2537 / 2539

页数：3

相关论文

共 21 条

[1] COMPLETE AMINO-ACID SEQUENCE OF P453-PLASMID-MEDIATED PIT-2 BETA-LACTAMASE (SHV-1) [J].

BARTHELEMY, M ;

PEDUZZI, J ;

LABIA, R .

BIOCHEMICAL JOURNAL, 1988, 251 (01) :73-79

[2] Diversity of TEM mutants in Proteus mirabilis [J].

Bonnet, R ;

De Champs, C ;

Sirot, D ;

Chanal, C ;

Labia, R ;

Sirot, J .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (11) :2671-2677

[3] MULTIPLY RESISTANT KLEBSIELLA-PNEUMONIAE STRAINS FROM 2 CHICAGO HOSPITALS - IDENTIFICATION OF THE EXTENDED-SPECTRUM TEM-12 AND TEM-10 CEFTAZIDIME-HYDROLYZING BETA-LACTAMASES IN A SINGLE ISOLATE [J].

BRADFORD, PA ;

CHERUBIN, CE ;

IDEMYOR, V ;

RASMUSSEN, BA ;

BUSH, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (04) :761-766

[4] TEM-28 from an Escherichia coli clinical isolate is a member of the his-164 family of TEM-1 extended-spectrum beta-lactamases [J].

Bradford, PA ;

Jacobus, NV ;

Bhachech, N ;

Bush, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (01) :260-262

[5] AUTOMATED-ANALYSIS OF ENZYME INACTIVATION PHENOMENA - APPLICATION TO BETA-LACTAMASES AND DD-PEPTIDASES [J].

DEMEESTER, F ;

JORIS, B ;

RECKINGER, G ;

BELLEFROIDBOURGUIGNON, C ;

FRERE, JM ;

WALEY, SG .

BIOCHEMICAL PHARMACOLOGY, 1987, 36 (14) :2393-2403

[6] A natural polymorphism in beta-lactamase is a global suppressor [J].

Huang, WZ ;

Palzkill, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (16) :8801-8806

[7] MORE EXTENDED-SPECTRUM BETA-LACTAMASES [J].

JACOBY, GA ;

MEDEIROS, AA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (09) :1697-1704

[8]

JARLIER V, 1988, REV INFECT DIS, V10, P867

[9] EXTENDED-SPECTRUM AND INHIBITOR-RESISTANT TEM-TYPE BETA-LACTAMASES - MUTATIONS, SPECIFICITY, AND 3-DIMENSIONAL STRUCTURE [J].

KNOX, JR .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (12) :2593-2601

[10]

LABIA R, 1988, REV INFECT DIS, V10, P885