The osteogenic effect of electrosprayed nanoscale collagen/calcium phosphate coatings on titanium

被引：90

作者：

de Jonge, Lise T. ^{[1
]}

Leeuwenburgh, Sander C. G. ^{[1
]}

van den Beucken, Jeroen J. J. P. ^{[1
]}

te Riet, Joost ^{[2
,3
]}

Daamen, Willeke F. ^{[4
]}

Wolke, Joop G. C. ^{[1
]}

Scharnweber, Dieter ^{[5
]}

Jansen, John A. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Periodontol & Biomat PB309, NL-6500 HB Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Nijmegen Ctr Mol Life Sci, Dept Tumor Immunol, NL-6500 HB Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Inst Mol & Mat, Dept Scanning Probe Microscopy, NL-6500 GL Nijmegen, Netherlands

[4] Radboud Univ Nijmegen, Med Ctr, Nijmegen Ctr Mol Life Sci, Dept Biochem 280, NL-6500 HB Nijmegen, Netherlands

[5] Tech Univ Dresden, Inst Mat Sci, Max Bergmann Ctr Biomat, D-01069 Dresden, Germany

来源：

BIOMATERIALS | 2010年 / 31卷 / 09期

关键词：

Calcium phosphate; Collagen; Nanocomposite; Biofilm; PLASMA-SPRAYED COATINGS; CALCIUM-PHOSPHATE; IN-VITRO; CELL-ADHESION; HYDROXYAPATITE; DEPOSITION; PROLIFERATION; IMPLANTS; CULTURE; SURFACE;

D O I：

10.1016/j.biomaterials.2009.11.114

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

For orthopedic and dental Implants. the ultimate goal is to obtain a life-long Secure anchoring of the implant in the native surrounding bone To this end, nanoscale calcium phosphate (CaP) and collagen-CaP (col-Call) composite coatings have been successfully deposited using the electrospray deposition (ESD) technique. In order to study to what extent the thickness of these coatings can be reduced Without losing coating osteogenic properties, we have characterized the mechanical and biological coating properties using tape tests (ASTM D-3359) and in vitro cell culture experiments. respectively Co-deposition of collagen significantly Improved coating adhesive and cohesive strength. resulting In a remarkably high coating retention Of up to 97% for coating thicknesses below 100 rim in vitro cell Culture experiments showed that electrosprayed CaP and col-CaP composite coatings enhanced osteoblast differentiation, leading to Improved mineral deposition This effect was most pronounced upon Co-deposition of collagen with CaP. and these coatings displayed osteogenic effects even for a coating thickness of below 100 nm (C) 2009 Elsevier Ltd All rights reserved

引用

页码：2461 / 2469

页数：9

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