Transferrin: structure, function and potential therapeutic actions

被引:388
作者
Gomme, PT [1 ]
McCann, KB [1 ]
机构
[1] CSL Ltd, Res & Dev, Bioplasma Div, Broadmeadows, Vic 3047, Australia
关键词
D O I
10.1016/S1359-6446(04)03333-1
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
There are many proteins that can multi-task. Transferrin, widely known as an iron-binding protein, is one such example of a multi-tasking protein. In this review, the multiple biological actions of transferrin, including its growth and cytoprotective activities, are discussed with the view of highlighting the potential therapeutic applications of this protein.
引用
收藏
页码:267 / 273
页数:7
相关论文
共 88 条
[1]   Transferrin Trojan horses as a rational approach for the biological delivery of therapeutic peptide domains [J].
Ali, SA ;
Joao, HC ;
Hammerschmid, F ;
Eder, J ;
Steinkasserer, A .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (34) :24066-24073
[2]   The inhibitory activity of serum to prevent bacterial adhesion is mainly due to apo-transferrin [J].
Ardehali, R ;
Shi, L ;
Janatova, J ;
Mohammad, SF ;
Burns, GL .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2003, 66A (01) :21-28
[3]   COMPARISON OF BEHAVIOR OF IN-111 AND FE-59-LABELED TRANSFERRIN ON INCUBATION WITH HUMAN AND RAT RETICULOCYTES [J].
BEAMISH, MR ;
BROWN, EB .
BLOOD, 1974, 43 (05) :703-711
[4]   Biological role of adduct formation of the ruthenium(III) complex NAMI-A with serum albumin and serum transferrin [J].
Bergamo, A ;
Messori, L ;
Piccioli, F ;
Cocchietto, M ;
Sava, G .
INVESTIGATIONAL NEW DRUGS, 2003, 21 (04) :401-411
[5]   Molecular characterization of a case of atransferrinemia [J].
Beutler, E ;
Gelbart, T ;
Lee, P ;
Trevino, R ;
Fernandez, MA ;
Fairbanks, VF .
BLOOD, 2000, 96 (13) :4071-4074
[6]  
Beutler Ernest, 2003, Hematology Am Soc Hematol Educ Program, P40
[7]   Synthesis and in vitro efficacy of transferrin conjugates of the anticancer drug chlorambucil [J].
Beyer, U ;
Roth, T ;
Schumacher, P ;
Maier, G ;
Unold, A ;
Frahm, AW ;
Fiebig, HH ;
Unger, C ;
Kratz, F .
JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (15) :2701-2708
[8]   TRANSFERRIN GENE-EXPRESSION VISUALIZED IN OLIGODENDROCYTES OF THE RAT-BRAIN BY USING INSITU HYBRIDIZATION AND IMMUNOHISTOCHEMISTRY [J].
BLOCH, B ;
POPOVICI, T ;
LEVIN, MJ ;
TUIL, D ;
KAHN, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (19) :6706-6710
[9]   Neurotrophic effects of transferrin on embryonic chick brain and neural retina cell cultures [J].
Bruinink, A ;
Sidler, C ;
Birchler, F .
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 1996, 14 (06) :785-795
[10]   Transferrin modifications and lipid peroxidation: Implications in diabetes mellitus [J].
Campenhout, AV ;
Van Campenhout, CM ;
Lagrou, AR ;
Keenoy, BMY .
FREE RADICAL RESEARCH, 2003, 37 (10) :1069-1077