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Mapping of the human P84 gene to the subtelomeric region of chromosome 20p

被引：9
作者：
Eckert, C [1 ]
Olinsky, S
Cummins, J
Stephan, D
Narayanan, V
机构：
[1] Childrens Hosp Pittsburgh, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Dept Pediat, Pittsburgh, PA 15260 USA
[3] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15260 USA
[4] Univ Pittsburgh, Dept Neurobiol, Pittsburgh, PA 15260 USA
来源：
SOMATIC CELL AND MOLECULAR GENETICS | 1997年 / 23卷 / 04期
关键词：
D O I：
10.1007/BF02674421
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
P84 is a novel neural adhesion molecule that may play an important role in synaptogenesis. We have recently cloned a murine cDNA encoding the P84 adhesion molecule. The human homologue of P84 has previously been isolated (by others) as a brain specific cDNA containing CCA repeats. We have mapped the human P84 gene to the subtelomeric region of chromosome 20p (20p13) by FISH. In addition, we have been able to place P84 onto the high resolution physical map of the human genome by utilizing the Unigene database. P84 maps to several YAC clones, between STS markers IB255 and WI-9632, and very close to the polymorphic marker D20S199, in an interval of less than I Mb on 20p13. P84 is a strong candidate gene for neurological disorders which map into this region.
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收藏
页码：297 / 301
页数：5
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