Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin-Yang interplay between inflammation and cancer

被引：163

作者：

Danese, S. ^{[2
]}

Mantovani, A. ^{[1
]}

机构：

[1] Ist Clin Humanitas IRCCS, Lab Inflammat & Immunol, I-20089 Milan, Italy

[2] Div Gastroenterol, Inflammatory Bowel Dis Unit, Milan, Italy

来源：

ONCOGENE | 2010年 / 29卷 / 23期

关键词：

inflammation; colon cancer; chemokines; TUMOR-NECROSIS-FACTOR; TOLL-LIKE RECEPTORS; IKK/NF-KAPPA-B; BLOCKING TNF-ALPHA; COLON-CANCER; ULCERATIVE-COLITIS; COLORECTAL-CANCER; EPITHELIAL-CELLS; MOUSE MODEL; INTERLEUKIN-10-DEFICIENT MICE;

D O I：

10.1038/onc.2010.109

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Colon cancer represents a paradigm for the connection between inflammation and cancer in terms of epidemiology and mechanistic studies in preclinical models. Key components of cancer promoting inflammation include master transcription factors (for example, nuclear factor kappa B, STAT3), proinflammatory cytokines (for example, tumor necrosis factor, interleukin-6 (IL-6)), cyclooxygenase-2 and selected chemokines (for example, CCL2). Of no less importance are mediators that keep inflammation in check, including IL-10, transforming growth factor beta, toll-like receptor and the IL-1 receptor inhibitor TIR8/SIGIRR, and the chemokine decoy and scavenger receptor D6. Dissection of molecular pathways involved in colitis-associated cancer may offer opportunities for innovative therapeutic strategies. Oncogene (2010) 29, 3313-3323; doi:10.1038/onc.2010.109; published online 19 April 2010

引用

页码：3313 / 3323

页数：11

共 116 条

[1] Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy [J].

Apetoh, Lionel ;

Ghiringhelli, Francois ;

Tesniere, Antoine ;

Obeid, Michel ;

Ortiz, Carla ;

Criollo, Alfredo ;

Mignot, Gregoire ;

Maiuri, M. Chiara ;

Ullrich, Evelyn ;

Saulnier, Patrick ;

Yang, Huan ;

Amigorena, Sebastian ;

Ryffel, Bernard ;

Barrat, Franck J. ;

Saftig, Paul ;

Levi, Francis ;

Lidereau, Rosette ;

Nogues, Catherine ;

Mira, Jean-Paul ;

Chompret, Agnes ;

Joulin, Virginie ;

Clavel-Chapelon, Francoise ;

Bourhis, Jean ;

Andre, Fabrice ;

Delaloge, Suzette ;

Tursz, Thomas ;

Kroemer, Guido ;

Zitvogel, Laurence .

NATURE MEDICINE, 2007, 13 (09) :1050-1059

[2] Expression of both TNF-α receptor subtypes is essential for optimal skin tumour development [J].

Arnott, CH ;

Scott, KA ;

Moore, RJ ;

Robinson, SC ;

Thompson, RG ;

Balkwill, FR .

ONCOGENE, 2004, 23 (10) :1902-1910

[3] Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation:: Evidence in Crohn disease and experimental colitis in vivo [J].

Atreya, R ;

Mudter, J ;

Finotto, S ;

Müllberg, J ;

Jostock, T ;

Wirtz, S ;

Schütz, M ;

Bartsch, B ;

Holtmann, M ;

Becker, C ;

Strand, D ;

Czaja, J ;

Schlaak, JF ;

Lehr, HA ;

Autschbach, F ;

Schürmann, G ;

Nishimoto, N ;

Yoshizaki, K ;

Ito, H ;

Kishimoto, T ;

Galle, PR ;

Rose-John, S ;

Neurath, MF .

NATURE MEDICINE, 2000, 6 (05) :583-588

[4]

Attiga FA, 2000, CANCER RES, V60, P4629

[5] Smoldering and polarized inflammation in the initiation and promotion of malignant disease [J].

Balkwill, F ;

Charles, KA ;

Mantovani, A .

CANCER CELL, 2005, 7 (03) :211-217

[6] Inflammation and cancer: back to Virchow? [J].

Balkwill, F ;

Mantovani, A .

LANCET, 2001, 357 (9255) :539-545

[7] TNF-α in promotion and progression of cancer [J].

Balkwill, Frances .

CANCER AND METASTASIS REVIEWS, 2006, 25 (03) :409-416

[8] Tumour necrosis factor and cancer [J].

Balkwill, Frances .

NATURE REVIEWS CANCER, 2009, 9 (05) :361-371

[9] Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study [J].

Beaugerie, Laurent ;

Brousse, Nicole ;

Bouvier, Anne Marie ;

Colombel, Jean Frederic ;

Lemann, Marc ;

Cosnes, Jacques ;

Hebuterne, Xavier ;

Cortot, Antoine ;

Bouhnik, Yoram ;

Gendre, Jean Pierre ;

Simon, Tabassome ;

Maynadie, Marc ;

Hermine, Olivier ;

Faivre, Jean ;

Carrat, Fabrice .

LANCET, 2009, 374 (9701) :1617-1625

[10] TGF-β suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling [J].

Becker, C ;

Fantini, MC ;

Schramm, C ;

Lehr, HA ;

Wirtz, S ;

Nikolaev, A ;

Burg, J ;

Strand, S ;

Kiesslich, R ;

Huber, S ;

Ito, H ;

Nishimoto, N ;

Yoshizaki, K ;

Nishimoto, N ;

Galle, PR ;

Blessing, M ;

Rose-John, S ;

Neurath, MF .

IMMUNITY, 2004, 21 (04) :491-501

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