Benzastatins A, B, C, and D: New free radical scavengers from Streptomyces nitrosporeus 30643 .1. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities

被引：65

作者：

Kim, WG

Kim, JP

Kim, CJ

Lee, KH

Yoo, ID

机构：

[1] KIST, KOREA RES INST BIOSCI & BIOTECHNOL, MICROBIAL CHEM RES GRP, TAEJON 305600, SOUTH KOREA

[2] SEOUL NATL UNIV, COLL AGR & LIFE SCI, DEPT FOOD SCI & TECHNOL, SUWON 441744, SOUTH KOREA

来源：

JOURNAL OF ANTIBIOTICS | 1996年 / 49卷 / 01期

关键词：

D O I：

10.7164/antibiotics.49.20

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

in the course of screening for free radical scavengers, rare metabolites, benzastatins A and B having aminobenzamide skeleton, and benzastatins C and D having tetrahydroquinoline skeleton, were isolated from the culture broth of Streptomyces nitrosporeus 30643. They showed inhibitory activity against lipid. peroxidation in rat liver microsomes. In the cell assay, benzastatins C and D inhibited glutamate toxicity in N18-RE-105 cells with EC(50) values of 2.0 and 5.4 mu M, respectively.

引用

页码：20 / 25

页数：6

共 21 条

[1] RAPID DIFFERENTIATION BETWEEN NOCARDIA + STREPTOMYCES BY PAPER CHROMATOGRAPHY OF WHOLE-CELL HYDROLYSATES [J].