Role of a CYP17 polymorphism in the regulation of circulating dehydroepiandrosterone sulfate levels in women with polycystic ovary syndrome

被引：50

作者：

Kahsar-Miller, M

Boots, LR

Bartolucci, A

Azziz, R

机构：

[1] Cedars Sinai Med Ctr, Dept Obstet & Gynecol, Los Angeles, CA 90048 USA

[2] Univ Alabama, Dept Obstet & Gynecol, Birmingham, AL 35294 USA

[3] Indiana Univ, Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46204 USA

[4] Univ Alabama, Sch Publ Hlth, Dept Biomath & Biostat, Birmingham, AL 35294 USA

来源：

FERTILITY AND STERILITY | 2004年 / 82卷 / 04期

关键词：

D O I：

10.1016/j.fertnstert.2004.05.068

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

We studied 259 consecutive unselected white patients with the polycystic ovary syndrome (PCOS) and 161 matched controls for a common polymorphism of CYP17, the gene encoding for P450c17alpha, and did not observe an important modulatory effect of this variant on circulating DHEAS. It does not appear that this common variant of CYP17, a T to C substitution in the 5' promoter region, plays a significant role in the adrenal androgen excess of PCOS. (C) 2004 by American Society for Reproductive Medicine.

引用

页码：973 / 975

页数：3

共 31 条

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STUDIES ON CHANGES IN THE CONCENTRATION OF SERUM ADRENAL ANDROGENS IN PUBERTAL TWINS [J].