Alginate-chitosan/hydroxyapatite polyelectrolyte complex porous scaffolds: Preparation and characterization

被引：190

作者：

Han, Jing ^{[1
]}

Zhou, Ziyou ^{[1
]}

Yin, Ruixue ^{[1
]}

Yang, Dongzhi ^{[1
]}

Nie, Jun ^{[1
,2
]}

机构：

[1] Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Key Lab Beijing City Preparat & Proc Novel Polyme, Beijing 100029, Peoples R China

[2] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2010年 / 46卷 / 02期

关键词：

Alginate; Chitosan; Hydroxyapatite; Polyelectrolyte complex; Scaffold; CHITOSAN SCAFFOLDS; TISSUE; FABRICATION; HYDROXYAPATITE/CHITOSAN; MICROCAPSULES; COMPOSITE; MEMBRANE; MATRIX;

D O I：

10.1016/j.ijbiomac.2009.11.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Porous scaffolds composed of alginate (AG) and chitosan (CS) were fabricated by combining the formation of polyelectrolyte complex (PEC) with freeze-drying The AG scaffold was used as a framework with uniformly distributed and interconnected pore structure The chitosan or chitosan/hydroxyapatite (CS/HA) composite solution was introduced into the pores of AG scaffold to form PEC scaffolds. FT-IR, XRD and XPS analysis confirmed that CS or CS/HA was coated on the AG scaffold surface Microstructure, porosity. mechanical strength and thermal stability of PEC scaffolds were also investigated The AG-CS PEC scaffold and Ca2+ crosslinked AG scaffold showed smaller average pore diameter and lower porosity than those of uncrosslinked AG scaffold Moreover, compared with Ca2+ crosslinked AG scaffold, AG-CS PEC scaffold exhibited higher mechanical strength and better thermal stability (C) 2009 Elsevier B V All rights reserved

引用

页码：199 / 205

页数：7

共 37 条

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Fabrication and characterization of DTBP-crosslinked chitosan scaffolds for skin tissue engineering [J].