Molecular evolution of the Myb family of transcription factors: Evidence for polyphyletic origin

被引：275

作者：

Rosinski, JA ^{[1
]}

Atchley, WR ^{[1
]}

机构：

[1] N Carolina State Univ, Dept Genet, Ctr Quantitat Genet, Raleigh, NC 27695 USA

来源：

JOURNAL OF MOLECULAR EVOLUTION | 1998年 / 46卷 / 01期

关键词：

Myb; evolution; phylogeny; transcription factors; oncogene;

D O I：

10.1007/PL00006285

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Myb family of proteins is a group of functionally diverse transcriptional activators found in both plants and animals that is characterized by a conserved DNA-binding domain of approximately 50 amino acids. Phylogenetic analyses of amino acid sequences of this family of proteins portray very disparate evolutionary histories in plants and animals. Animal Myb proteins have diverged from a common ancestor, while plants appear related only within the DNA-binding domain. Results imply a pattern of modular evolution of the Myb proteins centering on the possession of a helix-turn-helix motif. Based on this it is suggested that Myb proteins are a polyphyletic group related only by a "Myb-box" DNA-binding motif.

引用

页码：74 / 83

页数：10

共 33 条

[1]

AMARAVADI L, 1994, ONCOGENE, V9, P971

[2] TRYPTOPHANS IN MYB PROTEINS [J].

ANTON, IA ;

FRAMPTON, J .

NATURE, 1988, 336 (6201) :719-719

[3] PETUNIA-HYBRIDA GENES RELATED TO THE MAIZE REGULATORY C1-GENE AND TO ANIMAL MYB PROTOONCOGENES [J].

AVILA, J ;

NIETO, C ;

CANAS, L ;

BENITO, MJ ;

PAZARES, J .

PLANT JOURNAL, 1993, 3 (04) :553-562

[4] A NOVEL DNA-BINDING PROTEIN WITH HOMOLOGY TO MYB ONCOPROTEINS CONTAINING ONLY ONE REPEAT CAN FUNCTION AS A TRANSCRIPTIONAL ACTIVATOR [J].

BARANOWSKIJ, N ;

FROHBERG, C ;

PRAT, S ;

WILLMITZER, L .

EMBO JOURNAL, 1994, 13 (22) :5383-5392

[5] PHYLOGENY OF THE MAJOR TETRAPOD GROUPS - MORPHOLOGICAL DATA AND DIVERGENCE DATES [J].

BENTON, MJ .

JOURNAL OF MOLECULAR EVOLUTION, 1990, 30 (05) :409-424

[6] VIRAL MYB ONCOGENE ENCODES A SEQUENCE-SPECIFIC DNA-BINDING ACTIVITY [J].

BIEDENKAPP, H ;

BORGMEYER, U ;

SIPPEL, AE ;

KLEMPNAUER, KH .

NATURE, 1988, 335 (6193) :835-837

[7] The telobox, a Myb-related telomeric DNA binding motif found in proteins from yeast, plants and human [J].

Bilaud, T ;

Koering, CE ;

BinetBrasselet, E ;

Ancelin, K ;

Pollice, A ;

Gasser, SM ;

Gilson, E .

NUCLEIC ACIDS RESEARCH, 1996, 24 (07) :1294-1303

[8]

BISHOP JM, 1991, COLD SPRING HARB SYM, V56, P99

[9] MOLECULAR-CLONING, EXPRESSION AND INVITRO FUNCTIONAL-CHARACTERIZATION OF MYB-RELATED PROTEINS IN XENOPUS [J].

BOUWMEESTER, T ;

GUEHMANN, S ;

ELBARADI, T ;

KALKBRENNER, F ;

VANWIJK, I ;

MOELLING, K ;

PIELER, T .

MECHANISMS OF DEVELOPMENT, 1992, 37 (1-2) :57-68

[10] THE TRANSCRIPTIONAL CONTROL PROTEINS C-MYB AND V-MYB CONTAIN A BASIC REGION DNA-BINDING MOTIF [J].

CARR, MD ;

MOTT, RF .

FEBS LETTERS, 1991, 282 (02) :293-294

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