In vitro synergy of caspofungin and itraconazole against Aspergillus spp.:: MIC versus minimal effective concentration end points

被引:59
作者
Shalit, I
Shadkchan, Y
Samra, Z
Osherov, N [1 ]
机构
[1] Tel Aviv Univ, Sackler Sch Med, Dept Human Microbiol, IL-69978 Tel Aviv, Israel
[2] Tel Aviv Univ, Schneider Childrens Med Ctr Israel, IL-69978 Tel Aviv, Israel
[3] Tel Aviv Univ, Rabin Med Ctr, IL-69978 Petah Tiqwa, Israel
关键词
D O I
10.1128/AAC.47.4.1416-1418.2003
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Caspofungin and itraconazole were studied alone and in combination against 31 clinical isolates of Aspergillus spp. according to NCCLS M38-P guidelines. MICs and microscopic minimal effective concentrations (MECs) were recorded, and synergy was calculated by using both end points. Synergy or synergy to additivity was found in 30 of 31 isolates by using MIC end points. With MEC end points no synergy was found and indifference was detected in 26 of 31 strains.
引用
收藏
页码:1416 / 1418
页数:3
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