Efficacy trial of live, cold-adapted and inactivated influenza virus vaccines in older adults with chronic obstructive pulmonary disease: a VA cooperative study

被引：43

作者：

Gorse, GJ

O'Connor, TZ

Young, SL

Mendelman, PM

Bradley, SF

Nichol, KL

Strickland, JH

Paulson, DM

Rice, KL

Foster, RA

Fulambarker, AM

Shigeoka, JW

Kuschner, WG

Goodman, RP

Neuzil, KM

Wittes, J

Boardman, KD

Peduzzi, PN

机构：

[1] St Louis Univ, Med Ctr, Dept Vet Affairs, St Louis, MO 63110 USA

[2] Dept Vet Affairs, Cooperat Studies Program, Albuquerque, NM USA

[3] Dept Vet Affairs, Cooperat Studies Program, West Haven, CT USA

[4] Med Ctr, Dept Vet Affairs, Durham, NC USA

[5] MedImmune Vaccines Inc, Mountain View, CA USA

[6] Med Ctr, Dept Vet Affairs, Ann Arbor, MI USA

[7] Med Ctr, Dept Vet Affairs, Minneapolis, MN USA

[8] Med Ctr, Dept Vet Affairs, Birmingham, AL USA

[9] Med Ctr, Dept Vet Affairs, Richmond, VA USA

[10] Med Ctr, Dept Vet Affairs, Gainesville, FL USA

[11] Med Ctr, Dept Vet Affairs, Chicago, IL USA

[12] Med Ctr, Dept Vet Affairs, Salt Lake City, UT USA

[13] Dept Vet Affairs, Palo Alto, CA USA

[14] Med Ctr, Dept Vet Affairs, Boston, MA USA

[15] VA Puget Sound Hlth Care Syst, Seattle, WA USA

[16] Stat Collaborat, Washington, DC USA

来源：

VACCINE | 2003年 / 21卷 / 17-18期

关键词：

influenza virus; influenza vaccine; efficacy;

D O I：

10.1016/S0264-410X(02)00748-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We assessed whether trivalent live, cold-adapted influenza virus (CAIV-T) vaccine provides added protection when co-administered with trivalent inactivated influenza virus vaccine (TVV) in patients with chronic obstructive pulmonary disease (COPD). Subjects (N = 2215) were randomly assigned to receive either TVV intramuscularly (IM) and CAIV-T intranasally (TC), or TVV and placebo (TP). The vaccines were well-tolerated. Efficacy of TC compared to TP was not statistically significant and was 0.16 for any influenza virus strain (95% confidence limit (CL): -0.22, 0.43), 0.26 for A (H3N2) virus (95% CL: -0.17, 0.53), and -0.05 for type B virus (95% CL: -1.13, 0.48). However, there was a possible advantage for TC over TP in reducing respiratory consequences of an influenza season measured by pulmonary function and symptoms at end of study. Published by Elsevier Science Ltd.

引用

页码：2133 / 2144

页数：12

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