Recommendations for the clinical and laboratory diagnosis of VITT against COVID-19: Communication from the ISTH SSC Subcommittee on Platelet Immunology

被引：123

作者：

Nazy, Ishac ^{[1
,2
]}

Sachs, Ulrich J. ^{[3
]}

Arnold, Donald M. ^{[1
,2
]}

McKenzie, Steven E. ^{[4
]}

Choi, Phil ^{[5
,6
]}

Althaus, Karina ^{[7
,8
]}

Ahlen, Maria Therese ^{[9
]}

Sharma, Ruchika ^{[10
]}

Grace, Rachael F. ^{[11
]}

Bakchoul, Tamam ^{[12
]}

机构：

[1] McMaster Univ, Michael G DeGroote Sch Med, Dept Med, HSC 3H53,1280 Main St West, Hamilton, ON L8S 4K1, Canada

[2] McMaster Ctr Transfus Res, Hamilton, ON, Canada

[3] Giessen Univ Hosp, Dept Thrombosis & Haemostasis, Giessen, Germany

[4] Thomas Jefferson Univ, Cardeza Fdn Hematol Res, Philadelphia, PA 19107 USA

[5] Canberra Hosp, Haematol Dept, Canberra, ACT, Australia

[6] Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT, Australia

[7] Univ Tubingen, Med Fac Tuebingen, Transfus Med, Tubingen, Germany

[8] Ctr Clin Transfus Med Tuebingen ZKT gGmbH, Tubingen, Germany

[9] Univ Hosp North Norway, Norwegian Natl Unit Platelet Immunol, Tromso, Norway

[10] Med Coll Wisconsin, Versiti BloodCtr Wisconsin Pediat Hematol Oncol, Milwaukee, WI 53226 USA

[11] Harvard Med Sch, Dana Farber Boston Childrens Canc & Blood Disorde, Boston, MA 02115 USA

[12] Univ Hosp Tuebingen, Med Fac Tuebingen, Inst Clin & Expt Transfus Med, Tubingen, Germany

来源：

JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2021年 / 19卷 / 06期

关键词：

AstraZeneca ChadOx1 nCov-19 vaccine; COVID-19; platelet activation; thrombocytopenia; thrombosis; HEPARIN-INDUCED THROMBOCYTOPENIA; CONFIRMATION; IDENTIFICATION; ANTIBODIES; TOOL;

D O I：

10.1111/jth.15341

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Vaccine administration is under way worldwide to combat the current COVID-19 pandemic. The newly developed vaccines are highly effective with minimal adverse effects. Recently, the AstraZeneca ChadOx1 nCov-19 vaccine has raised public alarm with concerns regarding the rare, but serious, development of thrombotic events, now known as vaccine-induced immune thrombotic thrombocytopenia (VITT). These thrombotic events appear similar to heparin-induced thrombocytopenia, both clinically and pathologically. In this manuscript, the ISTH SSC Subcommittee on Platelet Immunology outlines guidelines on how to recognize, diagnose and manage patients with VITT.

引用

页码：1585 / 1588

页数：4

共 22 条

[1] Antibody-induced procoagulant platelets in severe COVID-19 infection [J].

Althaus, Karina ;

Marini, Irene ;

Zlamal, Jan ;

Pelzl, Lisann ;

Singh, Anurag ;

Haberle, Helene ;

Mehrlander, Martin ;

Hammer, Stefanie ;

Schulze, Harald ;

Bitzer, Michael ;

Malek, Nisar ;

Rath, Dominik ;

Bosmuller, Hans ;

Nieswandt, Bernard ;

Gawaz, Meinrad ;

Bakchoul, Tamam ;

Rosenberger, Peter .

BLOOD, 2021, 137 (08) :1061-1071

[2]

FRATANTONI JC, 1975, BLOOD, V45, P395

[3] Heparin-induced multiple electrode aggregometry is a promising and useful functional tool for heparin-induced thrombocytopenia diagnosis: Confirmation in a prospective study [J].

Galea, Vassiliki ;

Khaterchi, Amir ;

Robert, Francoise ;

Gerotziafas, Grigoris ;

Hatmi, Mohamed ;

Elalamy, Ismail .

PLATELETS, 2013, 24 (06) :441-447

[4]

GREINACHER A, 1991, THROMB HAEMOSTASIS, V66, P734

[5] Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination [J].

Greinacher, Andreas ;

Thiele, Thomas ;

Warkentin, Theodore E. ;

Weisser, Karin ;

Kyrle, Paul A. ;

Eichinger, Sabine .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (22) :2092-2101

[6] High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study [J].

Helms, Julie ;

Tacquard, Charles ;

Severac, Francois ;

Leonard-Lorant, Ian ;

Ohana, Mickael ;

Delabranche, Xavier ;

Merdji, Hamid ;

Clere-Jehl, Raphael ;

Schenck, Malika ;

Fagot Gandet, Florence ;

Fafi-Kremer, Samira ;

Castelain, Vincent ;

Schneider, Francis ;

Grunebaum, Lelia ;

Angles-Cano, Eduardo ;

Sattler, Laurent ;

Mertes, Paul-Michel ;

Meziani, Ferhat .

INTENSIVE CARE MEDICINE, 2020, 46 (06) :1089-1098

[7] Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (vol 395, pg 497, 2020) [J].

Huang, C. ;

Wang, Y. ;

Li, X. .

LANCET, 2020, 395 (10223) :496-496

[8]

KIEFEL V, 1987, BLOOD, V70, P1722

[9] Incidence of thrombotic complications in critically ill ICU patients with COVID-19 [J].

Klok, F. A. ;

Kruip, M. J. H. A. ;

van der Meer, N. J. M. ;

Arbous, M. S. ;

Gommers, D. A. M. P. J. ;

Kant, K. M. ;

Kaptein, F. H. J. ;

Van Paassen, J. ;

Stals, M. A. M. ;

Huisman, M. V. ;

Endeman, H. .

THROMBOSIS RESEARCH, 2020, 191 :145-147

[10] Thrombocytopenia following Pfizer and Moderna SARS-CoV-2 vaccination [J].

Lee, Eun-Ju ;

Cines, Douglas B. ;

Gernsheimer, Terry ;

Kessler, Craig ;

Michel, Marc ;

Tarantino, Michael D. ;

Semple, John W. ;

Arnold, Donald M. ;

Godeau, Bertrand ;

Lambert, Michele P. ;

Bussel, James B. .

AMERICAN JOURNAL OF HEMATOLOGY, 2021, 96 (05) :534-537

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