General synthesis and aggregation behaviour of a series of single-chain 1,ω-bis(phosphocholines)

被引：49

作者：

Drescher, Simon

Meister, Annette

Blume, Alfred

Karlsson, Goran

Almgren, Mats

Dobner, Bodo

机构：

[1] MLU Halle Wittenberg, Inst Pharm, D-06120 Halle, Germany

[2] MLU Halle Wittenberg, Inst Chem, D-06108 Halle, Germany

[3] Uppsala Univ, Dept Phys & Analyt Chem, S-75123 Uppsala, Sweden

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2007年 / 13卷 / 18期

关键词：

aggregation; alcohols; amphiphiles; lipids; synthetic methods;

D O I：

10.1002/chem.200601866

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis and physicochemical characterisation of a series of polymethylene-1,omega-bis(phosphocholines) with even-numbered chain lengths between 22 and 32 carbon atoms is described. Two new synthetic strategies for the preparation of long-chain 1,omega-diols as hydrocarbon building blocks are presented. The temperature-dependent self-assembly of the single-chain bolaamphiphiles was investigated by cryo transmission electron microscopy (cryo-TEM), differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR).

引用

页码：5300 / 5307

页数：8

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